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Regulation of APP Metabolism by ER Associated Degradation

The pathological Ab peptide that accumulates in senile plaques in Alzheimer’s disease (AD) brains is derived from a precursor protein APP. Although etiology of AD is complex, genetic evidence shows that duplication of the APP gene... ver más

28/02/2011

HELSINGIN YLIOPIST...

75K€

Presupuesto del proyecto: 75K€

Líder del proyecto

HELSINGIN YLIOPISTO No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2011-02-28 No tenemos la información de la convocatoria

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Líder del proyecto

HELSINGIN YLIOPISTO No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 75K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The pathological Ab peptide that accumulates in senile plaques in Alzheimer’s disease (AD) brains is derived from a precursor protein APP. Although etiology of AD is complex, genetic evidence shows that duplication of the APP gene locus leading to elevated levels of APP protein is sufficient to cause early-onset AD highlighting the importance of regulatory mechanisms. The events resulting in generation of Ab from APP are well characterized but the regulation of APP protein levels in cells is poorly understood. Previous studies suggest that a degradation pathway in the ER participates in the regulation of APP metabolism but the exact mechanism remains unknown. Recently, we have identified APP as a substrate for ER-associated degradation pathway (ERAD). Here, we will focus on characterization of the ERAD pathway of APP aiming at (1) identification of ERAD proteins that associate with APP, and (2) characterization of regulatory mechanisms that control ERAD of APP. We have identified an APP-binding protease HtrA2 that collaborates with the proteasome in ERAD of APP. Importantly, HtrA2-/- mice display a neurodegenerative phenotype and cells derived from these mice are increasingly susceptible to ER stress while secreting more Ab. Currently, there are no methods available for analyzing HtrA2 protease activity in cells and tissues. We will develop a fluorescence-based assay for HtrA2 activity to facilitate mechanistic studies linking HtrA2 to neurodegeneration. Modulation of APP metabolism in the early secretory pathway is an attractive therapeutic approach as it precedes other APP proteolytic processing events. Enhancement of ERAD could be used to downregulate APP metabolism and help the aging neurons in their battle against protein aggregation stress. Thus, the aims of this proposal are (1) to determine the role of ERAD as a catabolic pathway regulating APP levels and (2) to assess if changes in proteolytic activity of HtrA2 play a role in the pathogenesis of AD.

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