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Mind the Gap Mechanism and Impact of Ceramide Trafficking at the ER Mitochondri...

Mind the Gap Mechanism and Impact of Ceramide Trafficking at the ER Mitochondrial Interface A principal cause of failure in the treatment of cancer is that cancer cells develop resistance to chemo- and radiotherapy, leading to recurrence of the disease or even death. Sphingolipid molecules can modulate the ability of mal... ver más

31/07/2015

UOS

174K€

Presupuesto del proyecto: 174K€

Líder del proyecto

UNIVERSITAET OSNABRUECK No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2015-07-31 No tenemos la información de la convocatoria

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1 Participantes

UOS

0.00€ | Lider

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Líder del proyecto

UNIVERSITAET OSNABRUECK No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 174K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto A principal cause of failure in the treatment of cancer is that cancer cells develop resistance to chemo- and radiotherapy, leading to recurrence of the disease or even death. Sphingolipid molecules can modulate the ability of malignant cells to grow and resist anticancer regimens, with some molecules promoting tumorigenesis and others acting as tumor-suppressors. The tumor-suppressor activity of ceramides has prompted development of different formulations of synthetic ceramides in anticancer therapies, but the poor solubility of these compounds restricts their biocompatibility. Therefore, attention is increasingly focused on possibilities to manipulate cellular sphingolipid balances from within. The recent discovery of a ceramide sensor that protects cells against ceramide-induced cell death marks an important breakthrough. Disrupting sensor function causes accumulation of ceramides in the endoplasmic reticulum (ER) and their flow into mitochondria, triggering a mitochondrial pathway of apoptosis. While these results define the transfer of ER ceramides to mitochondria as a key determinant of cell fate, the molecular principles that govern ceramide trafficking at the ER-mitochondrial interface remain to be established. In this project, I aim to unravel the transport mechanism by which ER ceramides can reach mitochondria to initiate apoptosis. I will conduct a chemical screen employing photoactivatable and clickable ceramide analogues to identify ceramide-binding proteins operating at the ER-mitochondrial interface. As complementary approach, I will conduct a functional screen to search for proteins required for delivering ER ceramides to mitochondria. This screen is based on the principal that blocking expression of such proteins would prevent cells with a disrupted ceramide sensor from committing suicide. Finally, I will evaluate newly-identified components of the ceramide trafficking machinery as targets for modulating drug-induced apoptosis in tumors.

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