Hola,
¿eres nuevo aquí?

Registrate y conecta tu empresa con financiación pública, partners y proyectos.

Remin-T

Financiado

Dissecting the molecular basis of immunological memory in human T cells

T lymphocytes are essential for immunity to pathogens and malignancies. Activated T cells can retain a ‘memory’ imprint of their adversary (e.g. a virus), enabling them to respond more rapidly and vigorously to any subsequent enco... ver más

31/08/2025

ERASMUS MC

188K€

Presupuesto del proyecto: 188K€

Líder del proyecto

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-11-15

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

HORIZON-MSCA-2021-PF-01-01: MSCA Postdoctoral Fellowships 2021

I+D

Cerrada hace 3 años

0% 100% 100%

1 Participantes

ERASMUS MC

187.62K€ | Lider

Proyectos interesantes

PID2021-125757OB-I00 INTERACCIONES GENICAS Y PROTEICAS DE CD69 Y SUS REGIONES GEN... 157K€ Cerrado

SAF2016-80803-R ANALISIS DE UNA NUEVA FUNCION DE P21 COMO SUPPRESOR SELECTIV... 145K€ Cerrado

PID2021-125277OB-I00 DESCIFRANDO EL PAPEL Y LA REGULACION DE LA ARQUITECTURA DEL... 303K€ Cerrado

RTI2018-095902-B-I00 MECANISMOS TRANSCRIPCIONALES IMPLICADOS EN EL PAPEL INFLAMAT... 315K€ Cerrado

SAF2017-88086-R CELULAS MIELOIDES Y PLASTICIDAD EPIGENETICA: MECANISMOS E IM... 290K€ Cerrado

Th17 tissue metab Metabolic imprinting of Th17 cells in disease pathogenesis 266K€ Cerrado

Últimas noticias

29-11-2024: IDAE En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones

29-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 2 concesiones

29-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 37 concesiones

Duración del proyecto: 33 meses Fecha Inicio: 2022-11-15
Fecha Fin: 2025-08-31

Presupuesto del proyecto 188K€

Descripción del proyecto T lymphocytes are essential for immunity to pathogens and malignancies. Activated T cells can retain a ‘memory’ imprint of their adversary (e.g. a virus), enabling them to respond more rapidly and vigorously to any subsequent encounters. While memory T cell formation is critical for successful vaccination and anti-tumor immunity, dysfunctional memory T cells are a common feature of human disease, including allergy, autoimmunity and cancer. T cell activation emerges from changes in gene expression dictated by intricate chromatin dynamics. Recently, 3D chromatin folding emerged as a key regulator of transcriptional control by ensuring correct communication between regulatory elements and their target genes. How memory T cells leverage three-dimensionally organized chromatin configurations to achieve rapid re-activation of specific inflammatory genes is unclear. Hence, the molecular mechanisms that control and maintain immunological memory remain poorly understood. To address this issue, I propose an innovative molecular strategy to dissect immunological memory in primary human CD4+ T cells that combines cutting-edge genome-wide analyses of gene expression, chromatin state and three-dimensional (3D) genome folding with CRISPR/Cas9-based functional assays. This approach will generate the first integrated multidimensional epigenome atlas of a human T cell memory recall response, yielding molecular circuits of genes, regulatory elements and biological pathways underlying human immunological memory. Multimodal single cell genomics assays will reveal the nature of transcriptome-epigenome crosstalk in individual T cells and the heterogeneity of memory recall. These insights will force a breakthrough in our understanding of how human immune cells maintain specific transcriptional programs for launching rapid and tailored responses upon re-activation, and how this feeds into susceptibility to develop disease.

Conecta tu I+D

Entra hoy

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores