Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

BIOMA

Financiado

Cerrado

Bacteriocins Impact on Obesity and MicrobiotA

Alterations of the gut microbiota are implicated as a contributory factor in obesity-related metabolic dysregulation. Bacteriocins are antimicrobial peptides produced by bacteria of many genera, including several probiotic strains... ver más

31/01/2024

UCC

185K€

Presupuesto del proyecto: 185K€

Líder del proyecto

UNIVERSITY COLLEGE CORK NATIONAL UNIVERSITY... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2024-01-31

MSCA-IF-2020: Individual Fellowships

I+D

Cerrada hace 4 años

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UCC

184.59K€ | Lider

Proyectos interesantes

AGL2010-16525

Medical Technol...

Data Science

157K€ Cerrado

PID2020-114608RA-I00

Medical Technol...

Data Science

87K€ Cerrado

BFU2017-87958-P

Medical Technol...

Data Science

206K€ Cerrado

AGL2016-78311-R

Medical Technol...

Data Science

278K€ Cerrado

RTI2018-093873-A-I00

Medical Technol...

Public Health

145K€ Cerrado

PID2020-115403RB-C21

Medical Technol...

Data Science

173K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Duración del proyecto: 33 meses Fecha Inicio: 2021-04-29
Fecha Fin: 2024-01-31

Líder del proyecto

UNIVERSITY COLLEGE CORK NATIONAL UNIVERSITY... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 185K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Alterations of the gut microbiota are implicated as a contributory factor in obesity-related metabolic dysregulation. Bacteriocins are antimicrobial peptides produced by bacteria of many genera, including several probiotic strains. These peptides are often very specific and can kill target species without causing collateral damage to host bacterial populations. Since bacteriocins are gaining credibility as precise modulators of the human microbiome, bacteriocin-producer strains are an interesting strategy to address obesity prevention and/or treatment. However, rigorous experimental methods are required to assess this. The aim of BIOMA is to study the impact of a set of different bacteriocin-producing strains with probiotic traits, on the composition of the gut microbiota and on metabolic abnormalities in obesity, through the use of wild type strains and derived mutants that no longer produce the bacteriocins. The proposal involves two complementary approaches: 1) In vitro fermentation systems that simulates the anaerobic and dynamic environment of the distal colon will be used to assess the effect of bacteriocins production on taxonomic profiles and diversity of gut microbial populations. 2) In vivo male and female murine models will be used to study changes in microbiota and whether these changes are associated with a reduction in body weight gain and an improvement in inflammatory and metabolic profiles. A secondment at Artugen (interface of academia and industry) will be a first step to face the challenging incorporation of bacteriocin-producing probiotics into foods and pharmabiotics. From a clinical perspective, the under-utilization of bacteriocins can be ascribed to a lack of awareness of what they can achieve. The outcome of BIOMA will impact clinical practice in the foreseeable future, providing an overview of the potential of bacteriocins as microbiota modulators and as a possible strategy in the prevention/management of obesity and metabolic disorders.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores