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HYPERDIFF

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Cerrado

The Physiological Basis of Hypervirulence in Clostridium difficile a Prerequisi...

The Physiological Basis of Hypervirulence in Clostridium difficile a Prerequisite for Effective Infection Control Clostridium diffficile is currently wreaking havoc within European health systems due to the emergence of hyper virulent strains, responsible for more severe disease, higher relapse rates, increased mortality and greater resistanc... ver más

31/10/2011

THE UNIVERSITY OF...

4M€

Presupuesto del proyecto: 4M€

Líder del proyecto

THE UNIVERSITY OF NOTTINGHAM No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 7 Participantes

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2011-10-31 No tenemos la información de la convocatoria

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

7 Participantes

THE UNIVERSITY OF NOTTINGHAM

0.00€ | Lider

ISTITUTO SUPERIORE DI SANITA

N.D. | Participante

UPSud

N.D. | Participante

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Líder del proyecto

THE UNIVERSITY OF NOTTINGHAM No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 4M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Clostridium diffficile is currently wreaking havoc within European health systems due to the emergence of hyper virulent strains, responsible for more severe disease, higher relapse rates, increased mortality and greater resistance to antibiotics. Its impact in healthcare settings is considerable, in terms of morbidity, mortality and financial cost However, the physiological basis of pathogenesis is poorly understood due to an absence of mutational tools for functional genomic studies. This bottleneck has been solved by partner 1 who has developed the ‘ClosTron’, a highly efficient gene knock-out tool. This will be used to systematically inactivate those chromosomal genes which encode products hypothesised to be involved in pathogenesis, and an assessment of the consequences made in models of infection. To ascertain the prevalence of the identified hyper virulence traits in the human and animal population, epidemiological studies will be undertaken. Special attention will be paid to the wider human population to gauge the prevalence of community acquired C. difficile. The identity of the determinants responsible for hyper virulence would allow the derivation of diagnostic tests directed specifically at those factors directly responsible for their spread within the healthcare setting. They will also allow the formulation of therapeutic countermeasures that could be deployed to both prevent and treat disease outbreaks. The objectives of HYPERDIFF will be met by a consortium of the leading EU researchers on C. difficile. It brings together a multidisciplinary team from a range of sectors and 6 member states. They are composed of 4 Universities, 2 Government Institutes, and a commercial company, with the key skills needed to deliver the objectives of HYPERDIFF. In combination with the unique ClosTron system, these capabilities will propel Europe to the forefront of the field.

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