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ECOCHAR

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Characterization of widespread uropathogenic multidrug resistant Escherichia col...

Characterization of widespread uropathogenic multidrug resistant Escherichia coli clones by using a combined approach of conventional genotypic methods and high throughput technology One of the most worrying issues in public health is the recent and dramatic increase of hospital and community acquired infections mediated by uropathogenic (UPEC) multidrug resistant Escherichia coli clones. Recent epidemiologica... ver más

28/10/2012

ICETA

154K€

Presupuesto del proyecto: 154K€

Líder del proyecto

ICETA INSTITUTO DE CIENCIAS TECNOLOGIAS E AGR... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2012-10-28 No tenemos la información de la convocatoria

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ICETA

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Líder del proyecto

ICETA INSTITUTO DE CIENCIAS TECNOLOGIAS E AGR... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 154K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto One of the most worrying issues in public health is the recent and dramatic increase of hospital and community acquired infections mediated by uropathogenic (UPEC) multidrug resistant Escherichia coli clones. Recent epidemiological studies highlighted the implication of specific E. coli lineages from different genetic backgrounds in the spread of particular antibiotic resistance genes in wide geographic areas and settings. However, the reasons motivating their fast emergence and amplification and/or the factors influencing pathogenicity, adhesion and persistence are poorly understood, hindering the design of measures to curtail their spread. To gain insights into the role of these clonal groups, it would be necessary to extend the knowledge on their global distribution, identify transmission pathways and deepen in the characterization of their virulence and pathogenic profile. High-throughput methods could be valuable to complement genotypic methods in the identification of targets for clinically relevant clones’ detection, and to optimize global surveillance approaches. Although an appropriate validation and selection of statistical analysis methods is needed to consolidate their application in medical microbiology, fourier transform infrared spectroscopy (FTIR) has proved to be discriminatory at different bacterial taxonomic levels and might be a promising tool to assist large-scale epidemiological studies. We propose to apply a multidisciplinary and dynamic approach encompassing FTIR and conventional genotypic methods for identification and characterization of representative UPEC-multidrug resistant E. coli clones, recently responsible for the spread of extended-spectrum β-lactamases. This proposal includes fundamental research EU high priority areas with potential translation to human health, and the application of innovative and multidisciplinary strategies promoting research’s cooperativeness, inter-sectoral transfer of knowledge and global competitiveness.

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