Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

ICADIGE

Financiado

Cerrado

The Integron Cassette Dynamics and the Integrase Gene Expression

"Bacterial antimicrobial resistance has become one of the major concerns in modern medicine. It is currently responsible in Europe for 15 times as many deaths as AIDS every year. Not surprisingly this phenomenon is one of the Top... ver más

30/09/2014

194K€

Presupuesto del proyecto: 194K€

Líder del proyecto

INSTITUT PASTEUR No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2014-09-30 No tenemos la información de la convocatoria

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

0.00€ | Lider

Proyectos interesantes

EUIN2017-86485

Medical Technol...

Data Science

10K€ Cerrado

PID2020-117499RB-I00

Medical Technol...

Data Science

131K€ Cerrado

mARs

Medical Technol...

Data Science

2M€ Cerrado

SAF2017-85785-R

Medical Technol...

Data Science

194K€ Cerrado

PCI2021-122024-2A

Medical Technol...

Data Science

44K€ Cerrado

BIO2017-85056-P

Medical Technol...

Biotechnology

157K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Líder del proyecto

INSTITUT PASTEUR No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 194K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto "Bacterial antimicrobial resistance has become one of the major concerns in modern medicine. It is currently responsible in Europe for 15 times as many deaths as AIDS every year. Not surprisingly this phenomenon is one of the Top Six Health Topics for the eCDC. Bacteria have shown a remarkable evolvability towards resistance. One of the most worrisome mechanisms observed, is the integron, a highly efficient gene-recruitment platform. In addition to rising resistance, there are no encouraging perspectives in the drug discovery field. Thus, containment is the major asset in combating resistance. Nevertheless new and creative approaches are being assessed. A good example is the study of molecules against the integrase. A deep knowledge on the integrase’s activity and its regulation is at the basis of any major achievements in the field. This project aims to better understand integrons and to acquire new knowledge that will ultimately help combat antimicrobial resistance. The first set of experiments will unravel the behaviour of integrons in vivo. By developing a mouse model, we will study the influence of antibiotic therapy in the integrase induction through SOS response in the gut. Further work will be focused on the in vivo integron/plasmid synergy, as single stranded DNA transmission during conjugation can trigger integrase activation in vitro through SOS response. Such interaction is especially worrisome as many resistance plasmids carry resistance integrons.This data will help understand the behaviour of integrons and the dynamics of integrases in their natural environment. Altogether, the results of this project will mean a breakthrough in understanding the evolutionary potential integrons confer to bacteria. This knowledge will definitely help develop efficient tools to fight antimicrobial resistance."

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores