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The B cell memory program cell fate determinants and functional diversity of B...

The B cell memory program cell fate determinants and functional diversity of B cell subsets B cells are responsible for the humoral arm of the immune response and most successful vaccines in humans are antibody-based. Depending on the pathogen, specific B cell subsets are mobilized and a variety of innate, intermediate o... ver más

30/06/2015

INSERM

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHER... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2015-06-30 No tenemos la información de la convocatoria

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

INSERM

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Líder del proyecto

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHER... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto B cells are responsible for the humoral arm of the immune response and most successful vaccines in humans are antibody-based. Depending on the pathogen, specific B cell subsets are mobilized and a variety of innate, intermediate or adaptive responses are produced. In some cases these responses generate memory in anticipation of a re-encounter with the same pathogen. B cells can also present antigens to T cells, and enhance or suppress immune responses, depending in which T cell context they are primed. The present project aims to describe new innate-like and memory B cell subsets and to unravel the molecular switch allowing the differentiation and the long-term maintenance into the memory program. This will be done by combining approaches in both humans and mice, in order to reveal the analogies and the differences between these two immune systems. Our main specific aims are 1) to establish a reporter cell line that, by complementation with a cDNA library from human centrocytes and memory B cells, should allow the identification of a master gene able to trigger the memory program 2) to compare various antigenic and endogenous stimuli in terms of formation of various innate-like and memory subsets, using a mouse model that, by marking irreversibly B cells during an immune response, has allowed us to reveal new layers of B-cell memory 3) to study the endogenous and exogenous signals that support the development of marginal zone B cells in humans 4) to unravel the genes that govern long-term B cell memory, by isolating anti-vaccinia virus long-lived human memory B cells. The general ambition is to provide new insights into the complexity of the B cell compartment that should allow the improvement of B-cell targeted vaccination strategies.

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