Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

Hibernating_Synapses

Financiado

Synaptic resilience in Tau-induced neurodegeneration

Dementia is an enormous burden on society. Patients require life-long care and there is no cure or symptomatic treatment. At early phases, dementia is closely associated with synaptic degeneration and this correlates well with Tau... ver más

31/12/2027

VLAAMS INSTITUUT...

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

VIB VZW No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-06-16

ERC-2021-ADG: ERC ADVANCED GRANTS Scope:Objectives

I+D

Cerrada hace 3 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

VLAAMS INSTITUUT BIOTECHNOL...

2.50M€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

networkAD Network-based prediction of spreading of tau pathology in Al... 223K€ Cerrado

PID2020-117510RB-I00 PAPEL DE LOS FACTORES DE LA FAMILIA NR4 EN LOS DEFICITS SINA... 182K€ Cerrado

PID2021-123140NB-I00 DISFUNCION DEL SEGMENTO INICIAL DEL AXON Y NEURODEGENERACION... 163K€ Cerrado

PID2021-125875OB-I00 LAS SINAPSIS DEL HIPOCAMPO COMO FOCO CENTRAL EN LA ENFERMEDA... 145K€ Cerrado

sleepyTau A function for sleep-dependent tau dynamics 176K€ Cerrado

SAF2010-15676 REGULACION DE LA VIA PIP3 COMO ESTRATEGIA PARA REVERTIR LA D... 145K€ Cerrado

Duración del proyecto: 66 meses Fecha Inicio: 2022-06-16
Fecha Fin: 2027-12-31

Líder del proyecto

VIB VZW No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 3M€

Descripción del proyecto Dementia is an enormous burden on society. Patients require life-long care and there is no cure or symptomatic treatment. At early phases, dementia is closely associated with synaptic degeneration and this correlates well with Tau pathology in >20 Tauopathies. Interestingly, historic observations in hamsters and squirrels show that when they enter into hibernation, they also display Tau pathology and synaptic loss. Pathologists have pointed to these similarities; however, there is an important difference: synaptic loss is progressive in dementia, but reversible in hibernating animals. Capitalizing on recent technological advancements, I will unravel the mechanisms of this remarkable, yet understudied process of synaptic remodeling in hibernation and then use the pathways that reverse synapse loss in hamsters, to counteract Tau-induced synaptic decline in models of dementia. We will achieve these goals by first defining and studying the molecular and cellular drivers of synaptic remodeling during cycles of hibernation. This is based on innovative spatial transcriptomic and synaptic proteome analyses in hamster brains. We will then identify the human homologues of the hamster genes that reverse synaptic loss following hibernation and use a selection strategy in xenotransplanted human neurons and functional assays on custom-designed multielectrode arrays, to isolate genes rescuing Tau-induced neurodegeneration. This approach is bold, but feasible; my lab has a record of accomplishment in synaptic and neurodegeneration research and we already have strong preliminary work implicating specific pre-synaptic pathways in the types of Tau-dependent synaptic remodeling that we will study here. The gain is that we will uncover the mechanisms of a remarkable process of synaptic resilience, and apply this to rescue the synaptic loss in neurodegeneration. This project will define a conceptually new and unexplored class of therapeutic targets to tackle Tau-induced neuronal decline.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores