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SAF2009-10461

Financiado

ESTUDIO DE EXPRESION DIFERENCIAL DE PROTEINAS EN OBESIDAD Y PATOLOGIAS ASOCIADAS...

ESTUDIO DE EXPRESION DIFERENCIAL DE PROTEINAS EN OBESIDAD Y PATOLOGIAS ASOCIADAS IMPLICADAS EN LA VIA DE SEÑALIZACION UNFOLDED PROTEIN RESPONSE Y EN EL METABOLISMO LIPIDICO OBESITY IS INCREASING EXPONENTIALLY IN DEVELOPED COUNTRIES AND CONSTITUTES A PUBLIC HEALTH PROBLEM BY ENHANCING THE RISK FOR METABOLIC DISORDER SUCH AS INSULIN RESISTANCE AND TYPE 2 DIABETES (T2D), AS WELL AS CARDIOVASCULAR DISEAS... ver más

01/01/2009

CSIC

133K€

Presupuesto del proyecto: 133K€

Líder del proyecto

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 2-3 | 552M€

Financiación concedida El organismo AGENCIA ESTATAL DE INVESTIGACIÓN notifico la concesión del proyecto el día 2009-01-01

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CSIC

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30-11-2024: Cataluña Gestión For... Se ha cerrado la línea de ayuda pública: Gestión Forestal Sostenible para Inversiones Forestales Productivas para el organismo:

29-11-2024: IDAE En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones

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Líder del proyecto

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGA...

TRL 2-3 | 552M€

Presupuesto del proyecto 133K€

Descripción del proyecto OBESITY IS INCREASING EXPONENTIALLY IN DEVELOPED COUNTRIES AND CONSTITUTES A PUBLIC HEALTH PROBLEM BY ENHANCING THE RISK FOR METABOLIC DISORDER SUCH AS INSULIN RESISTANCE AND TYPE 2 DIABETES (T2D), AS WELL AS CARDIOVASCULAR DISEASE, OMENTAL ADIPOSE TISSUE HAS BEEN STRONGLY ASSOCIATED WITH THE DEVELOPMENT OF THESE OBESITY-RELATED COMORBIDITIES, WE HAVE SEARCHED FOR PROTEINS DIFFERENTIALLY EXPRESSED IN THESE TWO FAT DEPOTS USING TWO-DIMENSIONAL FLUORESCENCE DIFFERENCE GEL ELECTROPHORESIS (2D-DIGE) AND MASS SPECTROMETRY (MS), THIS ANALYSIS HAS REVEALED THE OVER-EXPRESSION OF PROTEINS IN THE OMENTAL FAT MAINLY RELATED TO METABOLIC PROCESSES SUCH AS GLUCOSE AND LIPID METABOLISM, LIPID TRANSPORT, PROTEIN FOLDING, RESPONSE TO STRESS AND INFLAMMATION, BASED ON THESE RESULTS WE AIMED TO STUDY THE POSSIBLE ASSOCIATION OF SEVERAL OF THESE PROTEINS WITH OBESITY AND/OR RELATED PATHOLOGIES, THE TARGET PROTEINS ARE FABP4 AND FABP5, WHICH PLAY AN IMPORTANT ROLE IN LIPID-MEDIATED SIGNALLING PATHWAYS IN THE ADIPOSE TISSUE, AS WELL AS PROTEINS FROM THE ¿UNFOLDED PROTEIN RESPONSE¿ (UPR) PATHWAY, ON THE OTHER HAND, OBESITY IS ASSOCIATED WITH A STATE OF CHRONIC, LOW-GRADE INFLAMMATION IN WHICH INFILTRATION OF MACROPHAGES INTO ADIPOSE TISSUE MIGHT CONTRIBUTE TO THE DEVELOPMENT OF INSULIN RESISTANCE AND T2D, AS SHOWN IN DIFFERENT EXPERIMENTAL MODELS, MACROPHAGES DISPLAY A WIDE VARIETY OF ACTIVITIES AND FUNCTIONS, PRIMARILY REFLECTING THEIR LOCAL METABOLIC AND IMMUNE MICROENVIRONMENT, RECENT STUDIES IN MICE MODELS HAVE SUGGESTED THAT ALTERNATIVELY ACTIVATED MACROPHAGES (M2) PROTECT AGAINST THE METABOLIC CONSEQUENCES OF OBESITY, WHILST CLASSICALLY ACTIVATED MACROPHAGES (M1) PREDISPOSE TO DEVELOPMENT OF DIET INDUCED OBESITY, INSULIN RESISTANCE, AND GLUCOSE INTOLERANCE, WE INTEND TO TEST THIS HYPOTHESIS IN THE HUMAN ADIPOSE TISSUE FROM OBESE PATIENTS WITH AND WITHOUT T2D, WE WILL ISOLATE STROMA VASCULAR CELLS (SVC) AND MATURE ADIPOCYTES FROM THE ADIPOSE TISSUE OF THESE SUBJECTS, AND ATTEMPT TO CHARACTERIZE THE ATM POPULATION OF SVC BY MEANS OF MACROPHAGE-SPECIFIC MARKERS DESCRIBED TO BE DIFFERENTIALLY EXPRESSED IN OBESE AND LEAN MICE, WE ARE ALSO INTERESTED IN ATM BECAUSE WE HAVE FOUND, FOR THE FIRST TIME, THAT FABP5 PROTEIN IS EXPRESSED IN HUMAN ATM, WE WOULD LIKE TO KNOW THE FUNCTION OF THIS PROTEIN IN MACROPHAGES AND THEIR POSSIBLE PARTICIPATION IN THE DIFFERENT ACTIVATION STATES OF ATMS FROM AN M2-POLARIZED STATE TO AN M1 PROINFLAMMATORY STATE, FABP5 TOGETHER WITH FABP4 PLAY AN IMPORTANT ROLE IN ADIPOSE TISSUE LIPID METABOLISM, THESE MOLECULES POTENTIALLY TARGET FATTY ACIDS TO TRANSCRIPTION FACTORS, SUCH AS MEMBERS OF THE PPAR FAMILY, AND FABPS THEMSELVES ARE CONTROLLED BY THESE TRANSCRIPTION FACTORS REGULATING NUMEROUS LIPID-MEDIATED BIOLOGICAL PROCESSES, OBESIDAD\TEJIDO ADIPOSO HUMANO\GRASA OMENTAL Y SUBCUTANEA\EXPRESION DE PROTEINAS\MACROFAGOS\ADIPOCITOS\VIA DE SEÑALIZACION UPR\METABOLISMO LIPIDICO

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