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Analysis of the interplay between genetic mutation and altered cellular metaboli...

Analysis of the interplay between genetic mutation and altered cellular metabolism in renal neoplasia Defining and characterising the defective genes in hereditary cancer syndromes has advanced our understanding of cellular function and disease mechanisms. Interestingly, some of these genes have been directly implicated in metabol... ver más

31/12/2017

UEDIN

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

THE UNIVERSITY OF EDINBURGH No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2017-12-31 No tenemos la información de la convocatoria

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2 Participantes

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Líder del proyecto

THE UNIVERSITY OF EDINBURGH No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 1M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Defining and characterising the defective genes in hereditary cancer syndromes has advanced our understanding of cellular function and disease mechanisms. Interestingly, some of these genes have been directly implicated in metabolic dysregulation, thus providing a link between genetic mutation and altered metabolism in cancer. One such syndrome, hereditary leiomyomatosis and renal cell cancer (HLRCC), is caused by germline mutations in the FH gene encoding the Krebs cycle enzyme fumarate hydratase. The aim of this proposal is to define pathways disrupted in HLRCC and within these to determine specific points, susceptible to genetic or chemical intervention, from which therapies might be derived to treat or prevent tumourigenesis. First, we will assess candidate mechanisms for FH-associated tumourigenesis which we have identified through recent studies, encompassing enzyme inhibition, protein modification, anti-oxidant signalling and altered energy metabolism. Secondly, to identify novel RCC associated mutations and clarify their relevance in the evolution and metabolism of RCC, transposon-based mutagenesis will be employed to induce RCCs in both wildtype and Fh1-deficient mice. Analyses will include histological analysis, metabolite profiling, and high resolution sequencing. Candidate genes will then be screened in relevant human RCC and pre-malignant lesions. Finally, a synthetic lethality screen will be performed in parallel with metabolic profiling to identify the pathways that are critical for the growth of FH-null cells. Taken together it is envisaged that this work will not only provide insights into this rare but aggressive disease but also inform on potential targets for intervention in more common cancers that are also characterised by metabolic dysregulation.

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