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Stress Granules

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Using Reconstituted Stress Granules to Gain Insight into the Molecular Pathology...

Using Reconstituted Stress Granules to Gain Insight into the Molecular Pathology of Neurodegenerative Diseases When cells experience stress, most protein synthesis pauses and so-called stress granules (SGs) form which store and protect mRNAs. SGs are crucial for stress adaptation and prevention of cell death. However, SGs are also implicat... ver más

31/01/2021

MPG

159K€

Presupuesto del proyecto: 159K€

Líder del proyecto

MAXPLANCKGESELLSCHAFT ZUR FORDERUNG DER WISSE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-01-31

MSCA-IF-2017: Individual Fellowships

I+D

Cerrada hace 7 años

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No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

MPG

159.46K€ | Lider

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Duración del proyecto: 34 meses Fecha Inicio: 2018-03-13
Fecha Fin: 2021-01-31

Líder del proyecto

MAXPLANCKGESELLSCHAFT ZUR FORDERUNG DER WISSE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 159K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto When cells experience stress, most protein synthesis pauses and so-called stress granules (SGs) form which store and protect mRNAs. SGs are crucial for stress adaptation and prevention of cell death. However, SGs are also implicated in age-related neurodegenerative diseases including amyotrophic lateral sclerosis and frontotemporal lobar degeneration. In these diseases, SGs persist longer than normal and turn into harmful aggregates which cells cannot dissolve. Despite the importance for human health, we only know very little about how normal SGs convert into disease-causing aggregates. Ground breaking work from the Hyman and Alberti labs could recently demonstrate that SGs behave like liquid droplets which solidify over time. Importantly, this transition is promoted by disease-associated mutations in SG components. SGs form through protein-protein interactions which critically depends on the Ras GTPase-activating protein-binding protein 1 (G3BP1). The Hyman and Alberti labs could recently generate G3BP1 droplets in vitro and could show that droplet formation is promoted by mRNAs. For the first time, we have a minimal SG system that can be used as a tool to mechanistically dissect SG formation and disease association. I propose harnessing this system to generate complex droplets that resemble physiological SGs. Ultimately, my objective is to elucidate how proteins with disease-causing mutations influence SG properties and dynamics, thus allowing me to identify the molecular changes that underlie neurodegenerative diseases. The proposed work is to take place in the teams of A Hyman and S Alberti, world leaders in the field of liquid droplets. Both groups are uniquely situated in the same institute which offers cutting-edge facilities and extensive training opportunities. The fellowship would crucially assist me in my future career objective: positioning myself as an expert in the field of granule biology and developing into an independent researcher in academia.

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