Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

COMMUNITY

Financiado

Cerrado

Unraveling the regulatory networks in Streptomyces that switch on antibiotic pro...

Unraveling the regulatory networks in Streptomyces that switch on antibiotic production on demand As Nature's medicine makers, Streptomyces bacteria produce a plethora of natural products, which we harness for clinical, biotechnological and agricultural applications, including 70% of the antibiotics. Streptomycetes still have... ver más

31/08/2027

ULEI

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

UNIVERSITEIT LEIDEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-09-01

ERC-2021-ADG: ERC ADVANCED GRANTS Scope:Objectives

I+D

Cerrada hace 3 años

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

Participantes

ULEI

Lider

Proyectos interesantes

BIO2014-56752-R

Medical Technol...

Biotechnology

218K€ Cerrado

EXPLOGEN

Medical Technol...

Biotechnology

1M€ Cerrado

PID2020-113062RB-I00

Medical Technol...

Biotechnology

230K€ Cerrado

RTI2018-093562-B-I00

Medical Technol...

Biotechnology

339K€ Cerrado

PID2019-107716RB-I00

Medical Technol...

Biotechnology

145K€ Cerrado

Zhou_PFL_Polyketides

Medical Technol...

Data Science

210K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Duración del proyecto: 59 meses Fecha Inicio: 2022-09-01
Fecha Fin: 2027-08-31

Líder del proyecto

UNIVERSITEIT LEIDEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 3M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto As Nature's medicine makers, Streptomyces bacteria produce a plethora of natural products, which we harness for clinical, biotechnological and agricultural applications, including 70% of the antibiotics. Streptomycetes still have a vast reservoir of unexplored biosynthetic potential, but many biosynthetic gene clusters (BGCs) are not expressed in the laboratory. To bring the chemical dark matter to the light, we need to discover the keys to unlock the expression of cryptic BGCs. I aim to add an entirely new dimension to genome mining, namely via understanding and exploitation of the regulatory networks that control natural product biosynthesis in Actinobacteria. My team discovered the concept of antibiotic production on demand, showing that plant hormones activate antimicrobials. Predicting when instead of what BGCs produce will allow clustering of BGCs based on their response to ecological signals. This can serve as a beacon for prioritising BGCs, and aid in the discovery of new biosynthetic pathways. I will tackle three major challenges:[1] The systems biology challenge is to elucidate the regulatory circuitry of streptomycetes and to reliably predict how BGCs are controlled[2] The metabolic challenge is to unwire the networks that tie carbon metabolism to antibiotic production, to bridge the gap from the complex polysaccharides in nature to the defined carbon sources of the laboratory.[3] The ecological challenge is to unravel the mechanisms and molecules via which plants invoke the power of Streptomyces' bioactive molecules to obtain protection against infections and pests, aimed at biological disease-suppression.COMMUNITY is an open science project that will help to elucidate whether the yet unexplored BGCs will deliver a paradigm shift in drug discovery, for application in agriculture and human health. Deliverables are innovative systems biology tools and detailed transcription factor networks, elicitors for drug screening and disease-suppressive microbes.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores