Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

ISOLM

Financiado

Cerrado

The neural circuit mechanisms of anti NMDA receptor encephalitis revealing the...

The neural circuit mechanisms of anti NMDA receptor encephalitis revealing the role of NMDA receptors in spatial memory in mice Since the discovery of the anti-NMDA receptor (anti-NMDAr) encephalitis (Dalmau et al., 2007) there has been a rapid expansion in both the number of patients diagnosed with this potentially fatal but treatable disease, and the ide... ver más

08/04/2017

CONSORCI INSTITUT...

223K€

Presupuesto del proyecto: 223K€

Líder del proyecto

CONSORCI INSTITUT D INVESTIGACIONS BIOMEDIQUE... Otra investigación y desarrollo experimental en ciencias naturales y técnicas organismos publicos

TRL 4-5 | 50K€

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2017-04-08 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

CONSORCI INSTITUT D INVESTIG...

0.00€ | Lider

Proyectos interesantes

RTI2018-095812-B-I00

Medical Technol...

Applied Physics

157K€ Cerrado

NovelNMDA

Medical Technol...

Applied Physics

1M€ Cerrado

BFU2015-63769-R

Medical Technol...

Applied Physics

157K€ Cerrado

SAF2010-20636

Medical Technol...

Applied Physics

242K€ Cerrado

BES-2012-052076

Medical Technol...

Applied Physics

43K€ Cerrado

NMDAR-synprun

Medical Technol...

Applied Physics

166K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Líder del proyecto

CONSORCI INSTITUT D INVESTIGACIONS BIOMEDIQUE... Otra investigación y desarrollo experimental en ciencias naturales y técnicas organismos publicos

TRL 4-5 | 50K€

Presupuesto del proyecto 223K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Since the discovery of the anti-NMDA receptor (anti-NMDAr) encephalitis (Dalmau et al., 2007) there has been a rapid expansion in both the number of patients diagnosed with this potentially fatal but treatable disease, and the identification of other autoimmune synaptic disorders (Lancaster & Dalmau 2012). Given the established central role of NMDAr in learning and memory, memory deficits are among the predominant symptoms of this disorder. Based on classical human studies, it is well established that the hippocampus is critical for long-term memory. Since the discovery of place-cells in the hippocampus of rodents (O’Keefe et al. 1971) the main focus of research on the neural basis of memory formation has become the understanding of how memory is encoded in the neural activity of these cells. We hypothesize that (i) NMDAr function is necessary for generation of new spatial representations of novel environments (Kentros et al. 1998) and (ii) for the retrieval of existing spatial representations on familiar environments. We will test this two-fold hypothesis using a recently established mouse model of human NMDAr antibody-mediated memory deficits (Mannara et al 2013). We will continuously inject anti-NMDAr antibodies obtained from patients with anti-NMDAr encephalitis while we image the simultaneous activity of hundreds of place-cells (Ziv et al 2013) as mice learn to navigate and differentiate between environments in order to find reward (Jercog et al. 2013). We will characterize the time course of the memory impairments and their neural-activity signature while animals are both recalling previously consolidated spatial memories and creating new ones. Our results will (i) help to understand the circuit mechanisms underlying some of the symptoms observed in patients with anti- NMDAr encephalitis and (ii) elucidate the exact role of NMDAr in the formation and retrieval of spatial memories in HP circuits.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores