Targeting treatment induced neuroendocrine prostate cancer
Current treatment options for prostate cancer include use of androgen deprivation therapies to block tumor growth but often the tumors become castration-resistant. Even the second generation antiandrogens that do have significant...
ver más
¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video
Proyectos interesantes
PCaProTreat
Multi omics molecular treatment targets for Prostate Cancer
171K€
Cerrado
RTI2018-097016-A-I00
BASES MOLECULARES DEL PAPEL DE LA POLIMERASA THETA EN EL CAN...
145K€
Cerrado
PTQ2021-011994
Identification and development of specific and potent inhibi...
116K€
Cerrado
CombaTCancer
Rational combination therapies for metastatic cancer
2M€
Cerrado
SAF2013-42946-R
CELULAS MADRE TUMORALES EN SARCOMAS: BUSQUEDA DE NUEVAS DIAN...
145K€
Cerrado
Información proyecto TARNEPC
Duración del proyecto: 33 meses
Fecha Inicio: 2020-03-04
Fecha Fin: 2022-12-31
Líder del proyecto
ITASUOMEN YLIOPISTO
No se ha especificado una descripción o un objeto social para esta compañía.
TRL
4-5
Presupuesto del proyecto
203K€
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
Current treatment options for prostate cancer include use of androgen deprivation therapies to block tumor growth but often the tumors become castration-resistant. Even the second generation antiandrogens that do have significant effect on castration-resistant tumor growth in patients are not curative. Approximately 25% of prostate cancer patients with castration-resistant disease treated with antiandrogens develop a form of prostate cancer that is completely independent of androgen receptor signaling that fuels the tumor growth. Analyses of the pathology and genomics of these patient tumors has identified that the tumor cells adapt cancer stem cell and neuronal cell characteristics. Currently, there are no treatment options for this patient group. Thus, development of novel strategies including selection of drugs that could be used to reduce the tumor growth and metastases in this patient group are desperately needed. This project aims at characterizing a novel therapeutic target against aggressive, the treatment resistant neuroendocrine prostate cancer. The success of this project may significantly benefit prostate cancer patients and provide cost-effective therapy options to be utilized in health service.