Innovating Works

BasicFit

Financiado
Targeting bicarbonate transport as a first-in-class therapeutic strategy to prom...
Targeting bicarbonate transport as a first-in-class therapeutic strategy to promote CD8+ T cell fitness and enhance cancer immunotherapy Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal cancer types. It is virtually resistant to any sort of therapy, including the most recent immunotherapies. These tumors are characterized by a strong... Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal cancer types. It is virtually resistant to any sort of therapy, including the most recent immunotherapies. These tumors are characterized by a strong hypoxic, nutrient poor, and acidic tumor microenvironment (TME), in which cytotoxic CD8+ T cells are excluded or absent. In the context of tumor acidity, the role of bicarbonate transporters, key regulators of pH homeostasis, has mostly been neglected so far. Supported by the ERC consolidator grant ImmunoFit, we recently unveiled that the metabolic editing of the TME via inhibition of a specific bicarbonate transporter in cancer cells represent a novel robust therapeutic strategy to mitigate the acidity of the TME, increase the fitness of CD8+ T cells, and render more effective the current immunotherapeutic regimens in pancreatic cancer. To progress on the path from ground-breaking research towards innovation we now propose to de-risk the target by delivering early lead compounds (i.e., blockers) with proven therapeutic efficacy and synergism with immunotherapies in several preclinical tumor models, to be valorized for add-on cancer therapy through follow-up R&D collaborations and/or licensing agreements with Pharmaceutical & Biotech companies. This will lead to the commercialization of our sciences and broad societal impact with the deliverable of a brand-new therapeutic approach and combination regimens which are urgently required to tackle tumor resistance or refractoriness vis-à-vis immunotherapies. ver más
29/02/2024
VLAAMS INSTITUUT...
150K€
Perfil tecnológico estimado
Duración del proyecto: 20 meses Fecha Inicio: 2022-06-27
Fecha Fin: 2024-02-29

Línea de financiación: concedida

El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-02-29
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
ERC-2022-POC1: ERC PROOF OF CONCEPT GRANTS1
Cerrada hace 3 años
Presupuesto El presupuesto total del proyecto asciende a 150K€
Líder del proyecto
VIB VZW No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5