Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

SBLIME

Financiado

Cerrado

Systems Biology of Lipids Metabolism

Lipids are a group of biomolecules found in every living cell, being the main structural components of cell membrane. Despite being so widespread, lipids are the most elusive among the biomolecules, because of the difficulty they... ver más

31/10/2012

EPFL

45K€

Presupuesto del proyecto: 45K€

Líder del proyecto

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2012-10-31 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

EPFL

0.00€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

ProteoLipidomics1 Proteolipidomic characterization of the regulatory circuitry... 221K€ Cerrado

CTQ2011-26603 UTILIZACION COMBINADA DE TECNICAS ANALITICAS Y QUIMIOMETRICA... 92K€ Cerrado

LipTransProMet The multi omics role of lipid transfer proteins in lipid met... 163K€ Cerrado

LIPIDOMICNET Lipid droplets as dynamic organelles of fat deposition and r... 16M€ Cerrado

SAF2015-70747-R ESTUDIO DE LOS MECANISMOS Y TRASCENDENCIA IN VIVO DE LAS ALT... 109K€ Cerrado

ONCOLIPID Oncolipidomics: Why is lipidomic dysregulation pattern in bl... 3M€ Cerrado

Líder del proyecto

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 45K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Lipids are a group of biomolecules found in every living cell, being the main structural components of cell membrane. Despite being so widespread, lipids are the most elusive among the biomolecules, because of the difficulty they present to be analyzed with most of classical biochemical techniques. Nevertheless, recent advancements in high-resolution chromatography and mass spectrometry have started to throw light on this large class of compounds (the full lipidome is suspected to be of the order of hundred thousand species). Their fundamental role in cellular and organism physiology, both in health and disease, has started to be appreciated. In particular new functions of lipids are being discovered, including regulatory and signaling functions. Their deregulation has been recognized as a key factor in several metabolic diseases, ranging from diabetes, obesity, hypertension, to coronary, neurological and Alzheimer's diseases. Therefore, it necessary to investigate how lipids function within the cell physiology and to study the coupling between global metabolism and lipid metabolism. Systems Biology provides the natural framework for such a integrated study of lipid metabolism and biosynthesis pathway. We propose to develop a set of mathematical and numerical tools useful to investigate the structure and regulation of the lipid biosynthesis pathway and to identify the key parameters (enzyme activities and substrate concentrations) responsible for the alteration of the distribution of lipids. The results of this analysis will be communicated to experimentalists and the collection of further experimental evidence will be concerted. Collected data will be used, in turns, to refine the models. The interaction between theory and experiments will provide new insight and quantitative understanding of the interplay between lipids metabolism and global cellular functions and its implication in health and disease.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores