Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

ONCOLIPID

Financiado

Oncolipidomics: Why is lipidomic dysregulation pattern in blood similar for vari...

Oncolipidomics: Why is lipidomic dysregulation pattern in blood similar for various cancers? Lipids are involved in numerous pathways of human metabolism that are related to pathological states. Alterations of lipid concentrations in the blood of cancer patients have been reported but the biological origin is still unknow... ver más

31/07/2028

UNIVERZITA PARDUBI...

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

UNIVERZITA PARDUBICE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-07-27

ERC-2022-ADG: ERC ADVANCED GRANTS Scope:Objectives

I+D

Cerrada hace 2 años

0% 100% 100%

1 Participantes

UNIVERZITA PARDUBICE

3.50M€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

CTQ2011-26603 UTILIZACION COMBINADA DE TECNICAS ANALITICAS Y QUIMIOMETRICA... 92K€ Cerrado

RTI2018-096323-B-I00 ESTUDIO DE PROTEINAS MODIFICADAS LIPIDICAMENTE: SONIC HEDGEH... 57K€ Cerrado

PDC2022-133402-I00 DESCIFRANDO EL LIPIDOMA HUMANO: CRYPT LIPID CODES PARA PREDE... 141K€ Cerrado

AURORA An integral solution for quantifying intracellular lipid tra... 150K€ Cerrado

CTQ2014-55279-R ROMPIENDO LOS LIMITES EN METABOLOMICA 152K€ Cerrado

EQC2018-005153-P Adquisición de un espectrómetro de análisis de masas de Alta... 453K€ Cerrado

Duración del proyecto: 60 meses Fecha Inicio: 2023-07-27
Fecha Fin: 2028-07-31

Líder del proyecto

UNIVERZITA PARDUBICE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 3M€

Descripción del proyecto Lipids are involved in numerous pathways of human metabolism that are related to pathological states. Alterations of lipid concentrations in the blood of cancer patients have been reported but the biological origin is still unknown. Deciphering the mechanisms of the lipid dysregulation mechanism could dramatically change oncology because it can open new avenues for cancer detection with subsequent effective treatment and drug development targeting dysregulated pathways. Early cancer diagnosis is one of the main unmet needs in medicine, which can improve the unfavorable prognosis of patients. The potential of lipidomics has not been fully explored yet, because analytical workflows have limitations in terms of accurate molar quantitation and insufficient coverage of the lipidome. Biologists predict up to 100,000 lipid species in nature, but current methods typically report less than 1% of this number. Here, we will develop novel approaches for quantitation of more than 2,000 lipids from >80 classes using 13C stable isotope labeled internal standards and ultrahigh-resolution methods in liquid or supercritical fluid chromatography, mass spectrometry, and ion mobility. The comprehensive characterization of lipidome will allow us to construct Cancer Lipidome Atlas (WP1). We will develop new Bayesian software for automated data processing and statistical evaluation applicable to the main lipidomic and metabolomic workflows (WP2). We will correlate lipidomics data with metabolomics, proteomics, and transcriptomics data to unravel why lipidomic dysregulation in blood has a similar pattern for various cancers (WP3). This strategy will be applied for the comparison of ten types of cancer with control samples in cell lines, animal models (mice and pigs), human samples (tissues and plasma), and extracellular vesicles. Our initial hypothesis is that the lower activity of CERS2 triggered by cancer cells can downregulate very long fatty acyl ceramides and other sphingolipids.

Conecta tu I+D

Entra hoy

¿Olvide mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores