Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

ProteoLipidomics1

Financiado

Cerrado

Proteolipidomic characterization of the regulatory circuitry of global lipid met...

Proteolipidomic characterization of the regulatory circuitry of global lipid metabolism The lipidome of eukaryotic cells consists of hundreds to thousands of lipid species that constitute membranes, store metabolic energy and function as bioactive molecules. The physiological importance of lipid complexity is demonst... ver más

31/03/2014

SDU

221K€

Presupuesto del proyecto: 221K€

Líder del proyecto

SYDDANSK UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2014-03-31 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

SDU

0.00€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

CTQ2011-26603 UTILIZACION COMBINADA DE TECNICAS ANALITICAS Y QUIMIOMETRICA... 92K€ Cerrado

LipTransProMet The multi omics role of lipid transfer proteins in lipid met... 163K€ Cerrado

SBLIME Systems Biology of Lipids Metabolism 45K€ Cerrado

LIPIDOMICNET Lipid droplets as dynamic organelles of fat deposition and r... 16M€ Cerrado

ONCOLIPID Oncolipidomics: Why is lipidomic dysregulation pattern in bl... 3M€ Cerrado

LipidAge Modulation of complex lipids to promote healthy aging 203K€ Cerrado

Líder del proyecto

SYDDANSK UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 221K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The lipidome of eukaryotic cells consists of hundreds to thousands of lipid species that constitute membranes, store metabolic energy and function as bioactive molecules. The physiological importance of lipid complexity is demonstrated by numerous diseases with inherent perturbations of lipid homeostasis including obesity, atherosclerosis, cancer and neurodegenerative disorders. How lipid complexity affects cell homeostasis and how cells regulate lipid metabolism on a lipidome-wide level remain unclear. The regulatory capacity of post-translational modifications in lipid metabolism is scarcely known, but an increasing body of evidence supports the premise that lipid enzyme activity can be dynamically regulated by protein phosphorylation. The main aim of this project is to functionally map the phosphorylation-dependent regulatory network of global lipid metabolism. To this end, we will develop a mass spectrometry-based proteolipidomics strategy for the yeast Saccharomyces cerevisiae. This platform will be designed for parallel quantitative analysis of lipid flux and the phosphorylation state of virtually all lipid enzymes and the kinases, phosphatases, and accessory regulatory factors involved in the cellular signalling networks. S. cerevisiae uses a relatively simple and conserved network of lipid metabolic pathways and is amenable to genetic manipulation and biochemical analyses, which make it a prime model organism for this study. This systems-level approach will enable us to (i) build a comprehensive regulatory map of global lipid metabolic networks, and (ii) delineate the dynamic regulation of lipid metabolism in key cellular events (e.g. cell division). Moreover, this work will help unravel the molecular design of conserved regulatory pathways of lipid metabolism and serve as a fundament for establishing analytical strategies applicable to studies in higher eukaryotes.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores