SCOBY DO
Financiado
Symbiotic Culture of Bacteria and Yeast Ecosystems for the development of Probio...
Symbiotic Culture of Bacteria and Yeast Ecosystems for the development of Probiotic Extracellular Vesicles
Fermented foods are used for many centuries all over the world for their contribution to longevity and digestive health. Regular consumption of fermented foods can combat dysbiosis and boost host’s immune response against various...
Fermented foods are used for many centuries all over the world for their contribution to longevity and digestive health. Regular consumption of fermented foods can combat dysbiosis and boost host’s immune response against various pathogens and associated diseases. However, they increase the microbiome of the digestive tract and can have adverse effects on immunosuppressed patients. Rather than single-strain probiotics, we will study Symbiotic Culture of Bacteria and Yeast Ecosystem (SCOBY) derived biomembrane-delimited nanostructures to obtain similar or enhanced beneficial effects. To that end, extracellular vesicles (EVs) harvested from kombucha, a fermented beverage based on tea and sugar produced with a SCOBY will be exploited for their antimicrobial properties against gastrointestinal bacterial infections and food-borne bacterial pathogens.
The experienced researcher is a microbiologist with strong academic background in the field of microbiology, infectious diseases, and bioinformatics who will team-up with the Institute of Biosciences and BioResources with considerable expertise in EV research to carry out a uniquely interdisciplinary research program. The research will realize the following objectives: 1. to set-up and optimize kombucha SCOBY cultures for the production of EVs, 2. to study the role of SCOBY-derived EVs in interspecies communication and their impact on gastrointestinal bacterial pathogens, and 3. to synthetize molecularly imprinted polymers specific for the enrichment of SCOBY-EVs. To our knowledge, none of these objectives has been addressed before and they all have the potential to expand the knowledge in the field and drive the research towards biotechnology applications in health and disease. The research objectives are integrated with concerted training objectives in EV research, mass spectrometry, MIPs design and synthesis, outreach program, dissemination events and considerable knowledge transfer in microbiology from the researcher.
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Duración del proyecto: 30 meses
Fecha Inicio: 2023-03-27
Fecha Fin: 2025-09-30
Fecha Fin: 2025-09-30
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-03-27
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
HORIZON-MSCA-2022-PF-01-01:
MSCA Postdoctoral Fellowships 2022
Cerrada
hace 2 años
Presupuesto
El presupuesto total del proyecto asciende a
189K€
Líder del proyecto
CONSIGLIO NAZIONALE DELLE RICERCHE
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5