Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

IntrAflamE

Financiado

Cerrado

Role of reactive microglia and intraneuronal amyloids on neuronal vulnerability...

Role of reactive microglia and intraneuronal amyloids on neuronal vulnerability in early Alzheimer’s disease The recently approved drugs for Alzheimer’s disease (AD), targeting amyloid plaques removal, only mildly slow patients’ cognitive decline as neuronal loss starts decades before plaque deposition. To delay AD onset before symptoms... ver más

04/05/2027

UNITO

Presupuesto desconocido

Líder del proyecto

UNIVERSITA DEGLI STUDI DI TORINO No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto

HORIZON-MSCA-2023-PF-01-01: MSCA Postdoctoral Fellowships 2023 ExpectedOutcome:Project results are expected to contribute to the following outcomes:

I+D

Cerrada hace 1 año

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

Participantes

UNITO

Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

MicroSyn-MIND Microglia-synapse molecular interactions in neurodegenerativ... 192K€ Cerrado

ADPROGRES Alzheimer disease progression Molecular studies of Abeta am... 75K€ Cerrado

PID2021-125785OA-I00 PAPEL DE LA MICROGLIA EN LA DISFUNCION SINAPTICA Y NEURONAL... 200K€ Cerrado

ADAMNEURON Study and Identification of ADAM10 as Neuronal secretase i... 100K€ Cerrado

PID2021-125986OB-I00 IMPLICACION DE LA GLIA EN TAUPATIA: NUEVAS DIANAS TERAPEUTIC... 175K€ Cerrado

BFU2009-07341 CARACTERIZACION DEL EFECTO DEL PEPTIDO BETA AMILOIDE SOBRE L... 69K€ Cerrado

Duración del proyecto: 23 meses Fecha Inicio: 2025-05-05
Fecha Fin: 2027-05-04

Líder del proyecto

UNIVERSITA DEGLI STUDI DI TORINO No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The recently approved drugs for Alzheimer’s disease (AD), targeting amyloid plaques removal, only mildly slow patients’ cognitive decline as neuronal loss starts decades before plaque deposition. To delay AD onset before symptoms development, prevention of neuronal death should be prioritised instead. An early AD pathological event is intraneuronal accumulation of amyloids (intraAβ) which can cause neuronal death at the pre-plaque stage. IntraAβ is only found in specific neuronal subtypes first to be lost in AD, suggesting it might underly their selective vulnerability. Reactive microglia could contribute to intraAβ as blocking neuroinflammatory processes in early AD reduces its accumulation. Whether microglia also contribute to intraAβ+ neurons selective loss is still unknown but could suggest repurposing of already available microglia targeting drugs for early neuroprotective therapies. I will test this hypothesis in 5xFAD mice, first confirming intraAβ accumulates in the neuronal subtypes selectively lost, as it occurs in humans. I will analyse the contribution of reactive microglia to intraAβ neurons death by pharmaceutically rescuing their reactivity and determine if intraAβ neurons-associated microglia express AD high-risk genes, which drive late AD pathology. Because AD affects women more, possibly due to their higher inflammatory response, the sex-specificity in the previous analyses will also be tested. Finally, I will establish microglia-containing human brain organoids to recapitulate this synergy in a in vitro human AD model, providing a foundation for future drug testing.By determining the potentially detrimental interplay between microglia reactivity and intraAβ+ neurons, using both in vivo and in vitro models, my project will lay the basis of extensive future work while defining my research niche. In the long term, my results will impact development of novel neuroprotective therapies for treating AD before neuronal loss.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores