Role of astrogliosis in the recurrence of brain tumors after microsurgical resec...
Role of astrogliosis in the recurrence of brain tumors after microsurgical resection
Malignant primary and secondary brain tumors represent the deadliest types of human cancer. Glioblastoma is the most common and the most lethal primary brain tumor. Standard of care is based on maximal surgical safe resection, fol...
ver más
¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video
Proyectos interesantes
Dcxglioma
Dissemination of proneural brain cancer cells implication...
194K€
Cerrado
Gal3-BrainMets
A novel immunotherapy against brain metastasis Anti Galecti...
170K€
Cerrado
SAF2015-62547-ERC
DECONSTRUYENDO LA ENFERMEDAD METASTATICA EN EL CEREBRO
62K€
Cerrado
SAF2011-23029
INTERPLAY BETWEEN MICROVASCULATURE, METABOLIC REPROGRAMMING...
109K€
Cerrado
PID2021-128549OB-I00
ESTUDIO DE LA RELACION DEL MICROAMBIENTE CEREBRAL CON EL GLI...
133K€
Cerrado
SAF2009-08629
CARACTERIZACION MOLECULAR DE LOS MECANISMOS IMPLICADOS EN LA...
73K€
Cerrado
Información proyecto GlioSurg
Duración del proyecto: 23 meses
Fecha Inicio: 2022-10-01
Fecha Fin: 2024-09-30
Líder del proyecto
INSTITUT CURIE
No se ha especificado una descripción o un objeto social para esta compañía.
TRL
4-5
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
Malignant primary and secondary brain tumors represent the deadliest types of human cancer. Glioblastoma is the most common and the most lethal primary brain tumor. Standard of care is based on maximal surgical safe resection, followed by fractionated radiotherapy, with concomitant and adjuvant systemic chemotherapy. Despite optimal treatment, the recurrence rate is higher than 90%. On the other hand, brain metastases (secondary brain tumors from distant organs) remain a substantial contributor to overall cancer mortality, being the main cause of death in up to 50% of affected patients. Research on the resistance to chemo and radiotherapy has been widely performed; however, studies on the impact of surgery on the cellular biological phenotype have been curiously neglected even if the standard of care requires that all patients receive surgical resection if possible. The contribution of the neuroinflammation to cancer progression is extensively studied. However its role after surgical injury remains to be elucidated. Therefore, we aim to mechanistically decipher the role of reactive astrocytes (key regulators of neuroinflammation) on the post-surgery recurrence of primary and secondary brain tumors. We will use intravital microscopy, digital pathology, genetic and pharmacological selective targeting of reactive astrocytes and ultimately, we will evaluate novel therapeutic approaches to improve clinical benefit.