Innovating Works

SAF2010-15881

Financiado
PAPEL DE LAS FORMAS CORTA Y SOLUBLE DE ENDOGLINA EN LA HOMEOSTASIS VASCULAR
ENDOGLIN (CD105) IS AN INTEGRAL MEMBRANE GLYCOPROTEIN THAT SERVES AS CO-RECEPTOR FOR MEMBERS OF THE TRANSFORMING GROWTH FACTOR BETA (TGF-) SUPERFAMILY OF PROTEINS, A MAJOR ROLE FOR ENDOGLIN IN REGULATING TGF--DEPEN... ENDOGLIN (CD105) IS AN INTEGRAL MEMBRANE GLYCOPROTEIN THAT SERVES AS CO-RECEPTOR FOR MEMBERS OF THE TRANSFORMING GROWTH FACTOR BETA (TGF-) SUPERFAMILY OF PROTEINS, A MAJOR ROLE FOR ENDOGLIN IN REGULATING TGF--DEPENDENT VASCULAR REMODELING AND ANGIOGENESIS HAS BEEN POSTULATED BASED ON: I) ENDOGLIN IS THE GENE MUTATED IN HEREDITARY HEMORRHAGIC TELANGIECTASIA (HHT) TYPE 1, A DISEASE CHARACTERIZED BY VASCULAR MALFORMATIONS; II) ENDOGLIN KNOCKOUT MICE DIE DURING THE EMBRYONARY PHASE DUE TO A DEFECTIVE ANGIOGENESIS; III) ENDOGLIN IS OVEREXPRESSED IN NEOANGIOGENIC VESSELS, DURING INFLAMMATION, AND IN SOLID TUMORS; AND IV) ENDOGLIN REGULATES THE EXPRESSION AND ACTIVITY OF ENDOTHELIAL NITRIC OXIDE SYNTHASE (ENOS), WHICH IS INVOLVED IN ANGIOGENESIS AND VASCULAR TONE, BESIDES THE PREDOMINANT FORM OF THE ENDOGLIN RECEPTOR (L-ENDOGLIN), TWO ADDITIONAL FORMS OF ENDOGLIN HAVE BEEN RECENTLY REPORTED TO DISPLAY A ROLE IN VASCULAR PATHOLOGY AND HOMEOSTASIS, ON ONE HAND, THE ALTERNATIVELY SPLICED SHORT ISOFORM (S-ENDOGLIN) AND ON THE OTHER HAND, A SOLUBLE ENDOGLIN FORM (SOL-ENDOGLIN) THAT PROBABLY IS PROTEOLYTICALLY CLEAVED FROM MEMBRANE BOUND ENDOGLIN, THE AIM OF THIS PROJECT IS TO ASSESS THE ROLE THAT THE S-ENDOGLIN AND SOL-ENDOGLIN PLAY IN REGULATING ANGIOGENESIS, VASCULAR REMODELING AND VASCULAR TONE, AS WELL AS TO ANALYZE THE MOLECULAR AND CELLULAR MECHANISMS SUPPORTING THESE EFFECTS, ver más
01/01/2010
USAL
448K€
Perfil tecnológico estimado

Línea de financiación: concedida

El organismo AGENCIA ESTATAL DE INVESTIGACIÓN notifico la concesión del proyecto el día 2010-01-01
Presupuesto El presupuesto total del proyecto asciende a 448K€
Líder del proyecto
UNIVERSIDAD DE SALAMANCA No se ha especificado una descripción o un objeto social para esta compañía.
Total investigadores 1146