Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

URDNA

Financiado

Origin and Protection of Unstable Repetitive DNA Elements During Sexual Reproduc...

Origin and Protection of Unstable Repetitive DNA Elements During Sexual Reproduction The objective of this proposal is to define the molecular basis behind the origin and protection of unstable repetitive DNA sequences during sexual reproduction. Eukaryotic genomes contain large amounts of repetitive elements that... ver más

30/09/2020

MPG

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

MAXPLANCKGESELLSCHAFT ZUR FORDERUNG DER WISSE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-09-30

ERC-StG-2014: ERC Starting Grant

I+D

Cerrada hace 10 años

0% 100% 100%

2 Participantes

MPG

1.50M€ | Lider

ARAFARMA GROUP

1.24M€ | Participante

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

PID2021-127486NB-I00 MECANISMOS DE ASISTENCIA A HORQUILLAS DE REPLICACION 218K€ Cerrado

BFU2013-41554-P REGULACION DE LA PRODUCCION DE ENTRECRUZAMIENTOS DURANTE LA... 182K€ Cerrado

BFU2010-18225 REGULACION DE LAS HORQUILLAS DE REPLICACION DEL DNA PARA LA... 133K€ Cerrado

BES-2011-049421 ROTURAS DE ADN ASOCIADAS A REPLICACION Y REPARACION POR RECO... 43K€ Cerrado

RED2018-102372-T INESTABILIDAD GENOMICA 22K€ Cerrado

BFU2013-49153-P MECANISMOS DE CONTROL DE LA REPLICACION DEL GENOMA EUCARIOTI... 339K€ Cerrado

Duración del proyecto: 65 meses Fecha Inicio: 2015-04-10
Fecha Fin: 2020-09-30

Líder del proyecto

MAXPLANCKGESELLSCHAFT ZUR FORDERUNG DER WISSE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto The objective of this proposal is to define the molecular basis behind the origin and protection of unstable repetitive DNA sequences during sexual reproduction. Eukaryotic genomes contain large amounts of repetitive elements that serve vital roles in cellular physiology. However, repetitive elements are intrinsically unstable, which is caused by a high likelihood for incorrect repair when DNA breaks form within repetitive elements. During sexual reproduction, numerous DNA breaks are actively introduced into the genome, and repetitive sequences particularly threaten genome stability during this specialized developmental program. We will use the repetitive budding yeast ribosomal (r)DNA array as a model locus to study repetitive DNA instability. Our previous work showed that the outermost elements of this large repetitive array (i.e. rDNA array boundaries) are DNA break ‘fragile sites’, which attract DNA breaks during sexual reproduction. Importantly, we isolated the first known enzymatic ‘anti-DNA break’ system, which minimizes DNA break formation at rDNA array boundaries and as such is crucially required to maintain genome stability. In the experiments outlined here, we will use a combination of genomics, molecular biology and biochemistry to: 1) Interrogate the origins of the vulnerability of the repetitive rDNA boundaries for DNA breaks, and 2) Define how a first-in-class ‘anti-DNA break’ system locally protects against DNA break formation. These studies will serve as a paradigm for repetitive DNA instability, yielding major insights into the general principles that govern protection of vulnerable genomic elements during sexual reproduction. It is well established that incorrect repair of DNA breaks involving repetitive sequences during sexual reproduction causes a myriad of human congenital disorders. Therefore, we foresee that insights gained from this work have the potential to help us understand the aetiology of human genetic disease.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores