Novel insights into sex specific and oestrogen dependent mechanisms in myocardia...
Novel insights into sex specific and oestrogen dependent mechanisms in myocardial ischaemia reperfusion injury
Acute myocardial infarction (MI) accounts for millions of morbidity and mortality cases worldwide. While the underlying pathophysiology of cardiomyocyte dysfunction and death during MI-related ischaemia/reperfusion injury (IRI), w...
ver más
¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video
Proyectos interesantes
DEP2015-71171-R
DESARROLLO Y CARACTERIZACION MOLECULAR DE UN NUEVO MODELO DE...
73K€
Cerrado
RTI2018-099401-B-I00
MECANISMOS DE CARDIOPROTECCION SENSIBLES AL ESTADO REDOX EN...
97K€
Cerrado
SAF2012-40208
EFECTOS FUNCIONALES Y MOLECULARES DE DISTINTAS FORMAS DE HDL...
94K€
Cerrado
microCardio
Functional high throughput analysis of the role of microRNAs...
149K€
Cerrado
SAF2011-30112
REGULACION DE LOS CANALES DE POTASIO HUMANOS QUE DETERMINAN...
97K€
Cerrado
Información proyecto SEXOGENIRI
Duración del proyecto: 38 meses
Fecha Inicio: 2021-03-19
Fecha Fin: 2024-05-31
Líder del proyecto
HASKOLI ISLANDS
No se ha especificado una descripción o un objeto social para esta compañía.
TRL
4-5
Presupuesto del proyecto
294K€
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
Acute myocardial infarction (MI) accounts for millions of morbidity and mortality cases worldwide. While the underlying pathophysiology of cardiomyocyte dysfunction and death during MI-related ischaemia/reperfusion injury (IRI), which occurs due to the restoration of coronary blood flow after MI, is well established, the relevance of sex-based differences in this context is poorly understood. In this action, we aim at understanding the effect of biological sex in the induction of a novel form of cell death in the setting of IRI. The project will examine both mouse and human hearts and will benefit from a range of techniques including, but not limited to in vivo surgery, in vitro cell line evaluation, state-of-the-art microscopy, mitochondrial respirometry and molecular biology methods. The content of the action will enable the researcher to restart his career and gain important academic, interpersonal and laboratory skills. It will also provide an opportunity for the researcher to publish in major journals and disseminate his findings to scientists and the public, which will ultimately help him establish himself in the field of cardiovascular science. The action also helps raise the research and academic profile of the host team and institution and contribute to the development of strong intra-European science networking. Overall, this action aims at contributing to the scientific progress of the researcher and pave the way for the identification of novel therapeutic targets for IRI with direct translational potential.