Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

ENDODEP

Financiado

Cerrado

Molecular mechanisms of endosome departure from the spindle in asymmetric cell d...

Molecular mechanisms of endosome departure from the spindle in asymmetric cell division During mitosis, cells can undergo asymmetric cell division, where daughter cells are endowed with different fates. Asymmetric division enables developing organisms to generate their particular diversity of cell types through a bal... ver más

31/10/2019

UNIGE

187K€

Presupuesto del proyecto: 187K€

Líder del proyecto

UNIVERSITE DE GENEVE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2019-10-31

MSCA-IF-2016: Individual Fellowships Objective:The goal of the Individual Fellowships is to enhance the creative and innovative potential...

I+D

Cerrada

0% 100%

Características del participante

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UNIGE

187.42K€ | Lider

Proyectos interesantes

BFU2016-76642-P

Medical Technol...

Applied Physics

230K€ Cerrado

PID2019-105609GB-I00

Medical Technol...

Biotechnology

242K€ Cerrado

CYTODEV

Medical Technol...

Applied Physics

169K€ Cerrado

PGC2018-094090-B-I00

Medical Technol...

Applied Physics

106K€ Cerrado

SAF2015-67756-R

Medical Technol...

Regenerative Me...

157K€ Cerrado

RYC-2010-07108

Medical Technol...

Applied Physics

192K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Duración del proyecto: 30 meses Fecha Inicio: 2017-04-07
Fecha Fin: 2019-10-31

Líder del proyecto

UNIVERSITE DE GENEVE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 187K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto During mitosis, cells can undergo asymmetric cell division, where daughter cells are endowed with different fates. Asymmetric division enables developing organisms to generate their particular diversity of cell types through a balanced combination of self-renewal and differentiation. Better understanding the mechanisms of asymmetric cell division will shed light on how cell renewal, differentiation and proliferation are controlled. In the longer term, this knowledge might enable regenerating defective cells in ageing and disease, generating cells of a particular identity for therapeutic purposes and tackling cell proliferation in cancer. The fate asymmetry results from a differential distribution of fate determinants between daughter cells. One way this segregation is implemented is through the directional trafficking of vesicles called endosomes along the microtubules of the mitotic spindle. While our understanding of the trafficking step has improved a lot through recent studies, it remains unclear how asymmetrically distributed endosomes at the spindle are ultimately released into the target daughter cell. This proposal aims at identifying the molecular mechanisms underlying this final, decisive step of asymmetric division: endosome departure from the spindle. We will work through four specific aims: 1 Characterise the dynamics of endosome departure under wild-type conditions, 2 Identify molecular interactions triggering departure, 3 Build a mathematical theory of the physics of departure,4 Test whether our proposed model can be generalised to other models of asymmetric division. Recent progress on directional endosomal trafficking has laid strong conceptual and practical frames to now focus on the next step of asymmetric division. Thus the proposed project is timely both through the question it addresses and the tool availability. This project is also intrinsically intersectorial, integrating physics, chemistry and mathematics to address a biological question.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores