Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

TraumiR

Financiado

Cerrado

microRNAs in susceptibility to traumatic stress

Traumatic stressors are important and prevalent risk factors for psychiatric disorders, such as post-traumatic stress disorder (PTSD). People differ strikingly in their susceptibility to develop PTSD after traumatic stress, howeve... ver más

31/05/2018

UNIVERSITEIT MAAST...

178K€

Presupuesto del proyecto: 178K€

Líder del proyecto

UNIVERSITEIT MAASTRICHT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2018-05-31

MSCA-IF-2015-EF: Marie Skłodowska-Curie Individual F...

I+D

Cerrada hace 9 años

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UNIVERSITEIT MAASTRICHT

177.60K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

SEEM Assessing the effect of early social environment on epigenet... 205K€ Cerrado

AGL2015-67945-P BIOMARCADORES EPIGENETICOS EN ENFERMEDADES PRIONICAS 113K€ Cerrado

SAF2014-56197-R EXPRESION GENICA DIFERENCIAL Y CATALOGO DE CAMBIOS EN ELEMEN... Cerrado

SAF2008-05674-C03-03 ANALISIS DE PERFILES DE METILACION EN GENES INVOLUCRADOS EN... 91K€ Cerrado

GENANX A cross species neurogenomics approach to anxiety 1M€ Cerrado

PCI2021-122087-2A PATIENT-CENTERED TARGETING OF EPIGENETIC VULNERABILITIES IN... 201K€ Cerrado

Duración del proyecto: 26 meses Fecha Inicio: 2016-03-07
Fecha Fin: 2018-05-31

Líder del proyecto

UNIVERSITEIT MAASTRICHT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 178K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Traumatic stressors are important and prevalent risk factors for psychiatric disorders, such as post-traumatic stress disorder (PTSD). People differ strikingly in their susceptibility to develop PTSD after traumatic stress, however the exact underlying biological mechanisms of differential susceptibility are unknown. The identification of biomarkers that distinguish between persons at high and low risk of developing PTSD following trauma exposure would enable more effective preventive strategies and early interventions. Epigenetic mechanisms have been proposed to underlie the relationship between exposure to traumatic stress and the susceptibility to develop PTSD. Recent work carried out by the host laboratory demonstrated that DNA methylation might regulate the impact of traumatic stress on gene expression and ultimately brain function. Based on this and the emerging role of miRNA as key epigenetic players in psychiatric disorders, I hypothesize that (i) susceptibility to traumatic stress exposure is associated with distinct miRNAs expression profiles with blood-brain correlation, (ii) experimental manipulation of miRNA expression levels in animals alters their susceptibility to traumatic stress. These hypotheses will be tested by a unique set of epigenetic epidemiological studies using prospective cohorts with longitudinal sampling schemes of military soldiers deployed to war, next to experimental animal studies. The proposed multidisciplinary and translational project will open the possibility of tapping into the mechanisms underlying differential susceptibility to traumatic stress through blood profiling. It has excellent prospects for yielding clinically relevant and usable biomarkers for the prediction of susceptibility to traumatic stressors. Moreover, the project will reinforce my foundation as a highly promising early career researcher by broadening my knowledge, skills, professional experience and network necessary to launch my own research group.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores