Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

MAPBYADMIXTURECHL

Financiado

Cerrado

Mapping Genes involved in Psychiatric Disorders by Admixture Linkage Disequilibr...

Mapping Genes involved in Psychiatric Disorders by Admixture Linkage Disequilibrium in Chilean populations Psychiatric disorders show a complex pattern of inheritance with genetic and environmental factors influencing disease risk. Despite the existence of numerous association studies aiming to identify genetic variants involved in the... ver más

31/07/2012

UPF

273K€

Presupuesto del proyecto: 273K€

Líder del proyecto

UNIVERSITAT POMPEU FABRA No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 322

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2012-07-31 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UPF

0.00€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

GenLife Genetics across the lifespan: Unraveling age-specific determ... 227K€ Cerrado

DPI2015-69585-R TRADUCIENDO INFORMACION DE ENFERMEDADES COMPLEJAS , COMPORTA... 73K€ Cerrado

SAF2015-68341-R GENETICA Y EPIGENETICA DE TRASTORNOS PSIQUIATRICOS: TRASTORN... 218K€ Cerrado

ATTENTIVE Distinguishing genetic overlap and causal relationship among... 264K€ Cerrado

CGL2011-27866 VARIABILIDAD POBLACIONAL DE REGIONES GENOMICAS IDENTIFICADAS... 97K€ Cerrado

PSI2011-30321-C02-02 VARIABILIDAD GENETICA ASOCIADA A REGULACION EMOCIAL, VINCULA... 48K€ Cerrado

Líder del proyecto

UNIVERSITAT POMPEU FABRA No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 322

Presupuesto del proyecto 273K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Psychiatric disorders show a complex pattern of inheritance with genetic and environmental factors influencing disease risk. Despite the existence of numerous association studies aiming to identify genetic variants involved in these disorders, inconsistencies in replication studies are common and just a few examples of links between gene variants and psychiatric disorders have been accepted. Several factors may be underlying the failure on replication: difficulties on the definition of clinical phenotypes, existence of distinct disease incidences or disease susceptibility variants among populations and, finally, differences in Linkage Disequilibrium and allele frequencies because of diverse population history. Whole genome association studies (WGAS) are powerful methods to map disease genes, however, these expensive techniques have been unsuccessful for psychiatric disorders. An alternative approach could be the use of mapping by admixture linkage disequilibrium (MALD), an efficient and economical method to localize disease-causing variants between two historically separated populations. MALD has already been successful for identification of disease loci in African American populations and, similarly, it is hoped to be a powerful tool in Latin American populations. We propose the design of an admixture panel of SNPs to map susceptibility genes for psychiatric disorders, particularly substance use and attention-deficit hyperactivity disorders, by the analysis of native (Aymara) and recently admixed populations from Chile. Furthermore, we also plan to assess the repercussions that different genetic structures among populations may have on the interpretation of association studies and, finally, we will search for signals of natural selection and adaptation pinpointing potential genes affecting behavioural traits. This collaborative and interdisciplinary project will also focus on the anthropological and cultural implications of the research and results obtained.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores