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NeurTransHet

Financiado

Cerrado

Investigating human neuronal transplantation integration and interaction at the...

Investigating human neuronal transplantation integration and interaction at the single cell level NeurTransHet will shed light on the heterogeneity of neuronal transplantations and the relationship with their environment. The aim of this project is to bring neuronal transplantation closer to clinical implementation by understa... ver más

06/12/2024

LMU MUENCHEN

163K€

Presupuesto del proyecto: 163K€

Líder del proyecto

LUDWIGMAXIMILIANSUNIVERSITAET MUENCHEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2024-12-06

MSCA-IF-2020: Individual Fellowships

I+D

Cerrada hace 4 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

LMU MUENCHEN

162.81K€ | Lider

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Duración del proyecto: 43 meses Fecha Inicio: 2021-04-20
Fecha Fin: 2024-12-06

Líder del proyecto

LUDWIGMAXIMILIANSUNIVERSITAET MUENCHEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 163K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto NeurTransHet will shed light on the heterogeneity of neuronal transplantations and the relationship with their environment. The aim of this project is to bring neuronal transplantation closer to clinical implementation by understanding the intricacies of individual transplanted cell contribution, and later applying this knowledge to engineer them. Neuronal loss underlies various brain disorders, such as Alzheimer’s disease, and injuries, such as traumatic brain injuries, resulting in life-long impairment. For example, dementia, a widespread (a new case every 3 seconds worldwide) condition stemming from neuronal loss, has devastating effects on the patients, their families and their communities. Thus, approaches aiming at replacing the lost neurons by transplantation are not only attractive from a health perspective, but also from a socio-economic standpoint. Many studies have explored neuronal transplantation, albeit with varying degrees of success. This is due to a lack in our understanding of how transplants integrate and interact with their host environment. Additionally, several studies gave evidence that transplanted cells are a heterogenous population, however, so far this heterogeneity has not been addressed in terms of function on integration and interaction. The recent advent of single cell transcriptomic technology, coupled with imaging techniques providing high-resolution spatial information, makes it possible to go beyond global interaction and closely dissect the individual neuronal transplants and their environment. Moreover, the possibility of transplanting cells of human origin in mice increases the clinical relevance of the results. During this two-year fellowship under the supervision of Prof. Dr. Magdalena Götz, who is a world-renowned scientist in neuronal cell replacement methodologies, I will transition into an independent research group leader investigating the role of cell heterogeneity in disease.

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