Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

NOVEXPAND

Financiado

Cerrado

Identification of novel factors to expand hematopoietic stem cells in vitro

Blood and marrow transplantation (BMT) has been used successfully to treat malignant blood disorders and genetic diseases. Although BMT has been effective, problems remain, for example lack of suitable donors and engraftment failu... ver más

31/12/2012

181K€

Presupuesto del proyecto: 181K€

Líder del proyecto

MAX IV Laboratory, Lund University No se ha especificado una descripción o un objeto social para esta compañía.

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2012-12-31 No tenemos la información de la convocatoria

0% 100% 100%

Características del participante

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

180.67K€ | Lider

Proyectos interesantes

STEMEXPAND

Medical Technol...

Biotechnology

4M€ Cerrado

PLEC2021-007518

Medical Technol...

Biotechnology

375K€ Cerrado

HSCORIGIN

Medical Technol...

Biotechnology

2M€ Cerrado

PDC2021-120817-I00

Medical Technol...

Biotechnology

133K€ Cerrado

ATR2023-143555

Medical Technol...

Biotechnology

994K€ Cerrado

SAF2016-75613-R

Medical Technol...

Biotechnology

436K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Líder del proyecto

MAX IV Laboratory, Lund University No se ha especificado una descripción o un objeto social para esta compañía.

Presupuesto del proyecto 181K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Blood and marrow transplantation (BMT) has been used successfully to treat malignant blood disorders and genetic diseases. Although BMT has been effective, problems remain, for example lack of suitable donors and engraftment failure. Cord blood (CB) contains hematopoietic stem cells (HSC) that can be used to transplant children. However, there are too few HSC in most CB samples to reliably engraft adult patients following BMT. Development of HSC expansion prior to transplantation would allow successful engraftment in patients that cannot be transplanted today due to a lack of a suitable donor. While some classical cytokines can maintain the number of HSC in culture, expansion of HSC in vitro will require discovery of novel factors that can increase more symmetrical divisions of HSC. In this project we will identify new factors that can expand HSCs by increasing the proliferation of immature HSC, using recent findings from embryonic stem (ES) cells and induced pluripotent stem (iPS) cells. ES/iPS cells are cell lines that have strong proliferation ability and are pluripotent in the presence of defined factors. Several genes expressed in ES/iPS cells have been identified as stem cell regulators, but a comprehensive analysis of all possible genes is essential to find additional factors that may be important for expansion of HSC. The screening will be done by using microarray analysis, subtraction assay, and over expression using cDNA libraries. Genes that are differentially expressed in immature ES cells and differentiated cells will be inserted into lentiviral vectors and transduced to HSC. The transduced HSCs will be analyzed with respect to inceased stem cell function using a transplantation assay in vivo. Findings from the project are expected to discover several novel regulatory molecules that will allow HSC expansion prior to transplantation. Successful HSC expansion will make most CB donor samples useful for adults requiring HSC transplantation therapy.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores