Homeoproteins as novel therapies for neurodegenerative diseases
With the ageing of the population, neurodegenerative diseases will be a huge societal, health and economic problem. There are no effective solutions that can stop the progression of these devastating diseases. At BrainEver we are...
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Información proyecto HOMEOBRAIN
Duración del proyecto: 24 meses
Fecha Inicio: 2022-10-24
Fecha Fin: 2024-10-31
Líder del proyecto
BRAINEVER
No se ha especificado una descripción o un objeto social para esta compañía.
Presupuesto del proyecto
6M€
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
With the ageing of the population, neurodegenerative diseases will be a huge societal, health and economic problem. There are no effective solutions that can stop the progression of these devastating diseases. At BrainEver we are developing a groundbreaking platform to treat neurodegenerative diseases based on a family of transcription factors called Homeoproteins (HPs). Homeoproteins are endogenous proteins expressed in diverse neuronal types, where they regulate age-dependent mechanisms related to neurodegeneration. When homeoproteins are injected into the central nervous system of animals with disease, neuronal survival and function is restored, halting degeneration. This suggests a huge potential as therapies for neurodegenerative diseases. In this project, we aim to develop and clinically validate a revolutionary therapy using the homeoprotein Engrailed-1, to treat patients with Amyotrophic Lateral Sclerosis (ALS) and Parkinson’s Disease (PD).