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Influenza tropism

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Cerrado

Evolutionary Determinants of Influenza Virus Pathogenesis and Tissue Tropism

Influenza A virus bears high morbidity and mortality burdens in humans following yearly seasonal epidemics and occasional yet potentially devastating pandemics. These burdens are a result of disease severity following infection in... ver más

31/10/2014

ERASMUS MC

184K€

Presupuesto del proyecto: 184K€

Líder del proyecto

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2014-10-31 No tenemos la información de la convocatoria

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No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

ERASMUS MC

0.00€ | Lider

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Líder del proyecto

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 184K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Influenza A virus bears high morbidity and mortality burdens in humans following yearly seasonal epidemics and occasional yet potentially devastating pandemics. These burdens are a result of disease severity following infection in individual hosts, and the size of influenza epidemics/pandemics at the population level. The relationships and feedbacks between influenza virus pathogenesis at the individual host level and influenza virus epidemiology at the population level are ill understood. Influenza virus tissue tropism contributes to determining which regions of the respiratory tract (from nasal cavity to deep lungs) are infected. The spatial location of influenza virus infection along the human respiratory tract is a determinant of the virus’ pathogenicity and transmissibility. While disease severity increases deeper down the respiratory tract, transmissibility appears favoured higher up. Both pathogenicity and transmissibility, associated with tissue tropism, contribute to the virus reproductive fitness, defining the size of the epidemic or pandemic. Therefore, strong selective pressures acting within hosts and at the population level likely shape tissue tropism to maximize influenza virus reproductive fitness. The aim of the project is to characterize these selective pressures and their interplay at the interface of within- and between-host dynamics, by combining experimental work and mathematical modelling. Key objectives are to determine the selective pressures associated with transmission and pre-existing immunity on influenza virus tissue tropism in an experimental setting; and determine the mutual interactions of these selective pressures by use of combined within- and between-host mathematical models. Modelling skills and knowledge will be transferred by the candidate to the European host. This project intends to clarify the cross-scale dynamics of influenza virus to better characterize and predict influenza morbidity and mortality burdens.

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