Enantioselective N-α C(sp3)-H Functionalization of Amides by Trifunctional Catal...
Enantioselective N-α C(sp3)-H Functionalization of Amides by Trifunctional Catalytic Systems
The trifunctional catalytic systems (TCS) consisting of bifunctional photocatalysts and transition metals will be designed to achieve the enantioselective N-α C(sp3)-H functionalization of amides (ENCHFA). Mechanistically, the bif...
ver más
¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video
Información proyecto ENCHFATCS
Duración del proyecto: 28 meses
Fecha Inicio: 2023-03-31
Fecha Fin: 2025-07-31
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
The trifunctional catalytic systems (TCS) consisting of bifunctional photocatalysts and transition metals will be designed to achieve the enantioselective N-α C(sp3)-H functionalization of amides (ENCHFA). Mechanistically, the bifunctional chiral hydrogen bonding-based aryl ketones will activate the amides to form α-amido radicals via HAT and control their reactivity in an enantioselective manner while transition metal will provide another opportunity to active substrates and accomplish the photocatalytic cycle via a radical relay. Combining chiral hydrogen bonding-based aryl ketones with Co catalysis, the protocol will develop the external oxidant-free enantioselective N-α C-H alkenylation, arylation and alkoxylation of amides with H2 evolution. Furthermore, the enantioselective N-α C-H trifluoromethylation of amides will be relized by merging chiral hydrogen bonding-based aryl ketones with Cu catalysis. The trifunctional catalytic systems will not only enrich the types of enantioselective C-H functionalization of amides, but also reveal the mechanism of trifunctional catalytic systems, as well as provide guidance for designing multiple systems in asymmetric catalysis.