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HD-SC

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Elucidating the Superior Colliculus-related network properties and modulation in...

Elucidating the Superior Colliculus-related network properties and modulation in Huntington's Disease mouse model to delay the onset and ameliorate severity of the motor symptoms Neurodegenerative movement disorders e.g. Huntington’s Disease (HD) predominantly involve progressive motor symptoms as a result of disrupted basal ganglia neuronal networks. These symptoms are accompanied by early occurring defic... ver más

30/09/2025

165K€

Presupuesto del proyecto: 165K€

Líder del proyecto

UNIVERSIDAD DE BARCELONA No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 327

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-04-26

HORIZON-MSCA-2022-PF-01-01: MSCA Postdoctoral Fellowships 2022 ExpectedOutcome:

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1 Participantes

165.31K€ | Lider

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Duración del proyecto: 29 meses Fecha Inicio: 2023-04-26
Fecha Fin: 2025-09-30

Líder del proyecto

UNIVERSIDAD DE BARCELONA No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 327

Presupuesto del proyecto 165K€

Descripción del proyecto Neurodegenerative movement disorders e.g. Huntington’s Disease (HD) predominantly involve progressive motor symptoms as a result of disrupted basal ganglia neuronal networks. These symptoms are accompanied by early occurring deficits in visual perception and oculomotor functions, which share neuronal circuits with motor domains, and can be used in the prediction of the onset and severity of HD pathogenesis. Therefore, understanding the early circuitry alterations in HD progression is crucial to develop new disease-modifying strategies. The superior colliculus (SC) is a sensorimotor structure that receives and integrates visual information to control reflexes and is involved in visual perception and oculomotor functions. Functional MRI and behavioural studies demonstrated that the HD symptomatic mouse model show alterations in the SC function, but its role in motor symptoms has not been directly addressed. The HD-SC project proposes that (i) SC is an important factor in the basal ganglia circuit alterations found in HD, (ii) topographically segregated SC outputs provide differential contributions to the motor and defensive behaviours, and (iii) temporal control of SC neuronal plasticity with novel phytochromes will cause delay and amelioration in motor symptoms in HD model. This will be addressed using a combination of mouse behavioural, histological and biochemical phenotyping to reveal the onset of SC-related alterations in the HD model. Then, by using DREADDS we will determine the differential representation of SC outputs in motor and defensive behaviour. Finally, we will test the capability of phytochromes to modulate SC neuronal plasticity and delay and ameliorate motor symptoms in the HD model. Overall, the HD-SC aims at bringing a spotlight to mechanisms causing symptomatic resilience in the HD model, which potentially could be implemented in other neurodegenerative movement disorders with basal ganglia circuit alterations.

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