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RTI2018-101273-J-I00

Financiado

DIGESTIBILIDAD IN VITRO Y ABSORCION DE CARBOHIDRATOS USANDO SISTEMAS ENZIMATICOS...

DIGESTIBILIDAD IN VITRO Y ABSORCION DE CARBOHIDRATOS USANDO SISTEMAS ENZIMATICOS HUMANOS. REGULACION DE LA RESPUESTA GLICEMICA MODULANDO ENZIMAS INTESTINALES THE NUMBER OF DIABETES-ASSOCIATED DEATHS AND METABOLIC-ASSOCIATED DISORDERS ARE INCREASING WORLDWIDE DUE TO THE HIGH CALORIC DIETS, THIS SITUATION IS GENERATING A HIGH CONCERN AND A POTENTIAL WAY TO MANAGE IT IS TO CONTROL DE GLYC... ver más

01/01/2018

CSIC

169K€

Presupuesto del proyecto: 169K€

Líder del proyecto

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 2-3 | 552M€

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo AGENCIA ESTATAL DE INVESTIGACIÓN notifico la concesión del proyecto el día 2018-01-01 No tenemos la información de la convocatoria

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CSIC

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Líder del proyecto

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 2-3 | 552M€

Presupuesto del proyecto 169K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto THE NUMBER OF DIABETES-ASSOCIATED DEATHS AND METABOLIC-ASSOCIATED DISORDERS ARE INCREASING WORLDWIDE DUE TO THE HIGH CALORIC DIETS, THIS SITUATION IS GENERATING A HIGH CONCERN AND A POTENTIAL WAY TO MANAGE IT IS TO CONTROL DE GLYCAEMIC RESPONSE, GLYCAEMIC RESPONSE VARIES DEPENDING ON DIFFERENT FACTORS SUCH AS CARBOHYDRATES STRUCTURES; THE ENZYMATIC MACHINERY TO HYDROLYSE CARBOHYDRATES, IN THE GASTROINTESTINAL SYSTEM, IT IS WELL-ESTABLISHED AND IN CONSEQUENCES, THE MOST SUSCEPTIBLE GLYOSIDIC LINKAGES TO BE HYDROLISED, HOWEVER, SOME CARBOHYDRATES THAT USED TO BE CONSIDERED AS NON-DIGESTIBLE SUCH AS SOME PREBIOTIC CARBOHYDRATES, IT HAS BEEN RECENTLY SHOWN TO BE HYDROLYSED BY SMALL INTESTINAL DISACCHARIDASES, DESPITE OF THESE EVIDENCES, THE IN VITRO DIGESTION METHODOLOGIES DO NOT CONSIDER THESE GROUP OF INTESTINAL ENZYMES, EVEN THOSE METHODS AIM TO EVALUATE THE PREBIOTIC ACTIVITY WHICH CAN RESULT IN AN OVERESTIMATION OF THIS VALUE, IT HAS BEEN ALSO BARELY DESCRIBED THE POTENTIAL POSITIVE EFFECT, BY PREBIOTICS CARBOHYDRATES, ON THE ACTIVITY AND EXPRESSION OF THESE DISACCHARIDES WHICH COULD OPEN A NEW ALTERNATIVE TO MANAGE GLYCAEMIC RESPONSE, TAKING INTO CONSIDERATION THAT: (1) THERE IS NO RELIABLE IN VITRO METHOD TO EVALUATE THE DIGESTIBILITY OF CARBOHYDRATES THAT CONSIDERS ALL THE GLYCOSYL-HYDROLYSES PRESENT IN THE HUMAN GASTROINTESTINAL TRACT AND THE PRESENCE OF SMALL INTESTINAL MUCUS; (2) PREBIOTIC ACTIVITIES ARE POTENTIALLY OVERESTIMATED DUE TO THE LACK OF PREVIOUS SMALL INTESTINAL DIGESTION, WHILST AT THE SAME TIME EXCLUDE NON DIGESTIBLE DISACCHARIDES THAT MAY HAVE PREBIOTIC POTENTIAL; (3) THE IMPORTANCE OF DIETARY FIBER INCREASES FOR COMMERCIAL PRODUCTION, IN LINE WITH THE PREBIOTIC MARKET AND THE GENERATION OF NEW POTENTIAL PREBIOTIC CARBOHYDRATES FROM SYNTHESIS AND BY-PRODUCTS OBTAINED FROM FOOD INDUSTRIES, AND (4) THERE IS A POTENTIAL FOR MODULATION OF DISACCHARIDASES ON THE HUMAN SMALL INTESTINAL THAT CAN RESULT IN THE LOWERING OF POSTPRANDIAL GLYCEMIA RESPONSE, AND, CONSEQUENTLY, CONTROLLING DIABETES AND OTHER METABOLIC DISORDERS ASSOCIATED WITH HIGH GLYCEMIC RESPONSE, THE MAIN AIM OF THIS PROPOSAL IS TO ENHANCE THE KNOWLEDGE OF CARBOHYDRATE DIGESTIBILITY AND AVAILABILITY TO THE LARGE INTESTINAL MICROBIOTA, THROUGH DEVELOPMENT AND VALIDATION OF A NOVEL IN VITRO DIGESTIBILITY TEST BASED ON THE DISACCHARIDASE MACHINERY OF THE HUMAN SMALL INTESTINAL BRUSH BORDER MEMBRANE, USING HUMAN CELL-BASED APPROACHES, THE FINDINGS OF THE PROPOSED STUDY COULD OPEN UP A RELIABLE AND ALTERNATIVE STRATEGY TO MANAGE THE GLYCEMIC RESPONSE AND ALSO PROVIDE RELIABLE EVIDENCE ON THE PREBIOTIC DIGESTIBILITY AND COLONIC AVAILABILITY TO ESTABLISH THEIR TRUE PREBIOTIC POTENTIAL AND CARRY OUT PROPERLY DESIGNED MECHANISTIC STUDIES, IN THE BEST TO MY KNOWLEDGE, THIS IS THE FIRST TIME THAT A PROJECT WILL STUDY THE EFFECT OF PREBIOTIC CARBOHYDRATES ON SMALL INTESTINE DISACCHARIDASES AND MONOSACCHARIDE TRANSPORTERS BY VALIDATING A RELIABLE IN VITRO DIGESTIBILITY METHOD AND STUDYING THE EFFECT OF PREBIOTIC CARBOHYDRATES ON THE POSTPRANDIAL GLYCAEMIC RESPONSE, DIGESTIBILIDAD\CARBOHIDRATOS\PREBIÓTICOS\RESPUESTA GLICÉMICA\ENZIMAS

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