Innovating Works

BFU2009-06958

Financiado
COFACTORES CELULARES DEL VIH
SEVERAL GENETIC AND ENVIRONMENTAL HOST FACTORS ARE IMPORTANT DETERMINANTS OF THE SUSCEPTIBILITY TO HIV INFECTION AND DISEASE PROGRESION, ALTHOUGH IT IS CLEAR THE EXISTENCE OF AN IMPORTANT GENETIC COMPONENT IN THE DIFFERENT RESPONS... SEVERAL GENETIC AND ENVIRONMENTAL HOST FACTORS ARE IMPORTANT DETERMINANTS OF THE SUSCEPTIBILITY TO HIV INFECTION AND DISEASE PROGRESION, ALTHOUGH IT IS CLEAR THE EXISTENCE OF AN IMPORTANT GENETIC COMPONENT IN THE DIFFERENT RESPONSES TO HIV INVECTION, THE KNOWLEDGE OF THE GENES INVOLVED IS LIMITED AND ONLY IN A FEW OF THEM ITS MECHANISM OF ACTION HAS BEEN CHARACTERIZED, THE IDENTIFICATION AND CHARACTERIZATION OF NEW HOST FACTORS WITH A ROLE IN THE COURSE OF HIV INFECTION IS RELLEVANT FOR A BETTER UNDERSTANDING OF THE MECHANISMS INVOLVED AND FOR THE DESCRIPTION OF NOVEL PUTATIVE TERAPHEUTIC TARGETS,THE MAIN OBJECTIVE OF OUR WORK IS THE IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF NEW DETERMINANT FACTORS OF THE DIFFERENCES IN SUSCEPTIBILITY TO HIV INFECTION AND THE TIME-COURSE OF ITS PROGRESSION TO AIDS AND THE VALIDATION OF IDENTIFIED COFACTORS AS POTENTIAL TARGETS FOR ANTI-HIV INTERVENTION, A GROUP OF GENES AND GENOMIC REGIONS WILL BE SELECTED AND GENOTYPED IN VARIOUS GROUPS OF HIV POSITIVE PATIENTS PHENOTIPICALLY WELL CHARACTERIZED AND THAT INCLUDE PROGRESSOR AND LONG TERM NON-PROGRESSOR AS COMPARED TO HEALTHY (HIV-) DONORS, BASED ON THE RESULTS OBTAINED FROM THE ASSOCIATION STUDY, THE MOST PROMISING CANDIDATES WILL BE SELECTED FOR ITS DETAILED FUNCTIONAL CHARACTERIZATION INCLUDING LOSS AND GAIN OF FUNCTION AND THEIR EFFECT IN PRIMARY LYMPHOID CELLS SUSCEPTIBLE TO HIV INFECTION,THIS PROPOSED MULTIDISCIPLINAR APPROACH WILL ALLOW THE DEFINITION OF GENETIC RISK FACTORS OF HIV INFECTION IN OUR POPULATION, IN ADDITION, IT WILL SHED LIGHT INTO THEIR BIOLOGICAL FUNCTION, BOTH CONFIRMING THE GENETIC RESULTS AND DETERMINING THE MECHANISM OF ACTION IN THE BIOLOGICAL CYCLE OF HIV, VIH\COFACTOR\GENOMICA\RNAI ver más
01/01/2009
FUNDACIO PRIVADA I...
373K€
Perfil tecnológico estimado

Línea de financiación: concedida

El organismo AGENCIA ESTATAL DE INVESTIGACIÓN notifico la concesión del proyecto el día 2009-01-01
Presupuesto El presupuesto total del proyecto asciende a 373K€
Líder del proyecto
FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SI... No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5 5M