Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

RODCELL

Financiado

Cerrado

Cellular and molecular mechanisms of the light response in photoreceptor cells o...

Cellular and molecular mechanisms of the light response in photoreceptor cells of the mammalian retina Genetic defects in proteins involved in the transduction of light in photoreceptor cells of the retina lead to severe retinal degenerations and blindness. Mutations that primarily affect rod function lead to retinitis pigmentosa... ver más

31/12/2011

FUNDACIO INSTITUT...

100K€

Presupuesto del proyecto: 100K€

Líder del proyecto

FUNDACIO INSTITUT D?INVESTIGACIO BIOMEDICA DE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 16M€

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2011-12-31 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

FUNDACIO INSTITUT D?INVESTIG...

0.00€ | Lider

Proyectos interesantes

BFU2008-04199

Medical Technol...

Applied Physics

191K€ Cerrado

BFU2011-26519

Medical Technol...

Applied Physics

54K€ Cerrado

CONESYSTEM

Medical Technol...

Applied Physics

50K€ Cerrado

RODRESET

Medical Technol...

Applied Physics

2M€ Cerrado

OPTOGENRET

Medical Technol...

Applied Physics

1M€ Cerrado

BLINDOPTOGEN

Medical Technol...

Applied Physics

45K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Líder del proyecto

FUNDACIO INSTITUT D?INVESTIGACIO BIOMEDICA DE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 16M€

Presupuesto del proyecto 100K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Genetic defects in proteins involved in the transduction of light in photoreceptor cells of the retina lead to severe retinal degenerations and blindness. Mutations that primarily affect rod function lead to retinitis pigmentosas. These diseases affect 1 in 4000 individuals, initially causing night blindness. As the gradual loss of rods eventually compromises cone cell viability, they lead to blindness. Mutations that affect cone function lead to cone dystrophies (CDs) or macular degenerations. There is no current cure for these diseases. The applicant will establish a lab in which the main interests will be: 1) study intracellular signaling in rod and cone photoreceptor cells in response to light, by combining mouse genetics with morphological, biochemical and electrophysiological analysis; and 2) use mouse models to study how genetic defects in these signaling pathways lead to retinal degeneration. In this frame, the first main aim of this proposal is to establish mouse models of the adCDs caused by mutations in the gene encoding Guanylate Cyclase Activating Protein 1 (GCAP1), a Ca2+-binding protein that regulates cGMP synthesis in rods and cones. By expressing mutant forms of the protein in murine rods, and subsequently in cones we will study the pathways leading to cell death in vivo. The second main aim is to study the mechanisms that govern arrestin intracellular localization in darkness and its massive redistribution in response to light. This is a defense mechanism of rod photoreceptors to adapt and to protect themselves to prolonged light exposures (e.g. during cone-operated vision), and its understanding will be relevant for the dark/light physiology or photoreceptor cells.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores