Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

AINIGMA

Financiado

Cerrado

Analysing Intravital Neuronal Protein Interactions in Metabolism and Apoptosis

The high energy demand of the brain predisposes it to a variety of diseases if energy supplies are interrupted. Neurons are particularly intolerant of inadequate energy supply and die or degenerate in either an acutely or chronica... ver más

31/10/2016

CHARITE UNIVERSIT...

162K€

Presupuesto del proyecto: 162K€

Líder del proyecto

CHARITE UNIVERSITAETSMEDIZIN BERLIN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2016-10-31 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

CHARITE UNIVERSITAETSMEDIZI...

0.00€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

BFU2016-77634-R INTEGRACION DE LA SEÑALIZACION CELULAR CON EL METABOLISMO MI... 109K€ Cerrado

EUIN2017-89486 REPROGRAMACION METABOLICA NEURONAL IN VIVO 3K€ Cerrado

NEUROMET Shaping of axonal complexity by a dynamic regulation of loca... 1M€ Cerrado

SAF2011-23550 MECANISMOS DE ELIMINACION DE SINAPSIS Y DINAMICA MITOCONDRIA... 182K€ Cerrado

BFU2008-00769 ESTUDIO DE UN NUEVO MECANISMO DE REGULACION DEL METABOLISMO... 536K€ Cerrado

MitoCyto Mitochondrial Precursor Proteins in the Cytosol as Major Det... 2M€ Cerrado

Líder del proyecto

CHARITE UNIVERSITAETSMEDIZIN BERLIN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 162K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The high energy demand of the brain predisposes it to a variety of diseases if energy supplies are interrupted. Neurons are particularly intolerant of inadequate energy supply and die or degenerate in either an acutely or chronically disturbed metabolic environment. Although neurodegenerative diseases are classically not considered to be caused by disturbed metabolism, bioenergetic defects are emerging as important pathophysiological mechanisms. Several glucose-metabolizing enzymes are involved in regulating cell survival or cell death in neurons and in other cell types, including the mitochondrial glucose-phosphorylating enzyme hexokinase II (HKII). A HKII-centered multiprotein complex, consisting of phosphoprotein enriched in astrocytes (PEA15) and possibly other proteins, has been demonstrated to function as a molecular switch regulating neuronal survival depending on the metabolic state. However, the molecular mechanism by which these protein:protein interactions are regulated remains elusive. The goal of AINIGMA and of the research proposed here is to unravel the intricate connection of glucose metabolism and the regulation of cell death pathways for neuronal viability or neuronal degeneration. By combining protein interaction studies in live induced pluripotent stem (iPS) cell-derived human neurons using novel biophysical tools such as fluorescence lifetime imaging microscopy (FLIM-FRET) and high throughput live cell RNA interference (RNAi) screens, the regulation of these protein interactions will be investigated. Finally, the impact of these interactions on neuronal survival under metabolic stress as well as the metabolic consequences of these protein interactions will be investigated. Therefore, AINIGMA will not only provide better insight into physiological and pathophysiological brain function but also form the basis for developing novel treatment approaches for acute and chronic neurodegenerative diseases.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores