CLAR
Financiado
A calorimeter at atomic resolution
Molecular interactions are at the basis of all biological processes and often include specific interactions between macromolecules (protein, RNA, DNA) and small-molecule ligands, such as cofactors, hormones, drugs, or metabolites....
Molecular interactions are at the basis of all biological processes and often include specific interactions between macromolecules (protein, RNA, DNA) and small-molecule ligands, such as cofactors, hormones, drugs, or metabolites. Detailed and quantitative knowledge of these interactions is critical for a molecular understanding of these biological processes and developing new therapeutic solutions. A complete comprehension of molecular recognition requires a full characterization of the geometry and dynamics of the molecular complex. This includes not only the internal dynamics of each partner but also the dynamics at the interface, which to date remain mostly unexplored experimentally.The physical chemistry frame for studying intra- and inter-molecular interactions is thermodynamics. The extent to which two molecules interact is dictated by the Gibbs energy change (ΔG) of the interactions, which is composed of enthalpic (ΔH) and entropic (ΔS) terms.X-ray crystallographic and NMR structures provide a detailed description of the static interactions associated with enthalpic contributions. However, up to now, the entropic components remain difficult to address experimentally.The overarching goal of this proposal is to develop a calorimeter at atomic resolution.To achieve that goal, a new NMR spectroscopy approach, relying mainly on the nuclear Overhauser effect, will be developed. It is anticipated that quantitative thermodynamic measurements within molecules and molecular complexes will open a new avenue in the fundamental understanding of how atomistic mechanism(s) create a function.Beyond the fundamental findings, we foresee applications in translational medicine, drug design, and computer-assisted molecular design.
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Duración del proyecto: 59 meses
Fecha Inicio: 2023-06-01
Fecha Fin: 2028-05-31
Fecha Fin: 2028-05-31
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-06-01
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
ERC-2022-COG:
ERC CONSOLIDATOR GRANTS
Cerrada
hace 2 años
Presupuesto
El presupuesto total del proyecto asciende a
3M€
Líder del proyecto
UNIVERSITAT WIEN
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5