Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

PSYCHIAPROTEGENOMIC

Financiado

Cerrado

Trancriptional control of dendritic arbors morphology in pathogeny and therapy o...

Trancriptional control of dendritic arbors morphology in pathogeny and therapy of neuropsychiatric diseases Neuropsychiatric disorders affect 25% of the population sometime during their life. Aberrant dendritic arbors appear in mental disorders. Although the psychopathological mechanisms are not completely understood, it has been sugges... ver más

02/02/2012

FUNDACIO PRIVADA P...

110K€

Presupuesto del proyecto: 110K€

Líder del proyecto

FUNDACIO PRIVADA PER LA RECERCA I LA DOCENCIA... Otras actividades asociativas n.c.o.p. asociacion

TRL 4-5 | 50K€

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2012-02-02 No tenemos la información de la convocatoria

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

FUNDACIO PRIVADA PER LA RECE...

0.00€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

BFU2008-01103 CONTROL TRANSCRIPCIONAL DE LA MORFOLOGIA DE LOS ARBOLES DEND... 109K€ Cerrado

TRANS-PSYCH Transcriptional Regulation Assessed in Neuronal Subtypes in... 1M€ Cerrado

SAF2009-13609-C04-04 CONTRIBUCIONES COMPUTACIONALES A LA GENERACION DE NUEVOS ENF... 133K€ Cerrado

SAF2010-20840-C02-01 EXPRESION GENICA Y VARIANTES GENOMICAS ASOCIADAS CON ESQUIZO... 151K€ Cerrado

MapGen Determining Genetic Bases of Differential Response to Antips... 308K€ Cerrado

TACtIK Trace Amine Associated Receptor 1 TAAR1 agonists in a chem... 213K€ Cerrado

Líder del proyecto

FUNDACIO PRIVADA PER LA RECERCA I LA DOCENCIA... Otras actividades asociativas n.c.o.p. asociacion

TRL 4-5 | 50K€

Presupuesto del proyecto 110K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Neuropsychiatric disorders affect 25% of the population sometime during their life. Aberrant dendritic arbors appear in mental disorders. Although the psychopathological mechanisms are not completely understood, it has been suggested that changes in gene expression contribute to the development and therapy. Several evidences, including the applicant own studies, suggest that misregulation of Sp4 transcription factor could be involved in the pathogenesis and therapy of affective disorders by controlling dendritic patterning. The applicant will explore the possibility that Sp4 and other transcriptional regulators might be altered in postmortem human brains of patients with mental disorders. This research pretends also to investigate the capability to regulate dendritic development by altered novel factors and psychotropic treatment. This project we will test the hypothesis that mood stabilizer and antipsychotic drug leads to a physiological dendritic patterning, in part, through the stabilization/activation of Sp4 transcription factor which leads to changes in expression of genes important for the pathogenesis and therapy of neuropsichiatric disorders. To address that hypothesis (a) we will study whether the levels of Sp4 transcription factor protein or other factors are altered in postmortem brain tissue from patients with schizophrenia or affective disorders. (b) We will perform a novel quantitative proteomic approach (SILAC) and gene expression arrays in postmortem brain of neuropsychiatric patients and whether the new hits module dendritic patterning. (c) And also, we will study the effect of mood stabilizers and antipsychotics on dendritic morphology by Sp4-dependent mechanism. These studies will give a new insight in the transcriptional programs controlled by lithium which may regulate dendritic morphology and, will provide the regulation of Sp4 u others factors as a possible mechanism involved in the pathogenesis and therapy of neuropsychiatric disorders.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores