Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

CellMechanoControl

Financiado

Cerrado

The physical basis of cellular mechanochemical control circuits

Biological cells possess a chemical sense of smell and a physical sense of touch. Structure, dynamics, development, differentiation and even apoptosis of cells are guided by physical stimuli feeding into a regulatory network integ... ver más

31/05/2019

UGOE

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

GEORGAUGUSTUNIVERSITAT GOTTINGEN STIFTUNG OFF... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2019-05-31 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UGOE

0.00€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

RTI2018-099718-B-I00 PAPEL DE LOS CANALES MECANO/OSMOSENSIBLES EN LAS FUNCIONES C... 290K€ Cerrado

BFU2014-57019-P BIOMECANICA DE LA MORFOGENESIS EN DROSOPHILA 175K€ Cerrado

Scaling-Sensitivity Developmental scaling of cell mechanosensitivity in epitheli... 2M€ Cerrado

BFU2017-82075-ERC REDES MECANOQUIMICAS EN LA MEMBRANA PLASMATICA 68K€ Cerrado

PID2020-114533GB-C22 MECANISMOS MECANOSENSIBLES EN LA COORDINACION DE LA ACTIVIDA... 99K€ Cerrado

ForceDelivery Mechanosensitive proteins as a pathway to mechano-targeted d... 184K€ Cerrado

Líder del proyecto

GEORGAUGUSTUNIVERSITAT GOTTINGEN STIFTUNG OFF... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Biological cells possess a chemical sense of smell and a physical sense of touch. Structure, dynamics, development, differentiation and even apoptosis of cells are guided by physical stimuli feeding into a regulatory network integrating biochemical and mechanical signals. Cells are equipped with both, force-generating structures, and stress sensors including force-sensitive structural proteins or mechanosensitive ion channels. Pathways from force sensing to structural and transcriptional controls are not yet understood. The goal of the proposed interdisciplinary project is to quantitatively establish such pathways, connecting the statistical physics and the mechanics to the biochemistry. We will measure and model the complex non-equilibrium mechanical structures in cells, and we will study how external and cell-generated forces activate sensory processes that (i) act (back) on the morphology of the cell structures, and (ii) lead to cell-fate decisions, such as differentiation. The most prominent stress-bearing and -generating structures in cells are actin/myosin based, and the most prominent mechanoactive and -sensitive cell types are fibroblasts in connective tissue and myocytes in muscle. We will first focus on actin/myosin bundles in fibroblasts and in sarcomeres in developing heart muscle cells. We will observe cells under the influence of exactly controlled external stresses. Forces on suspended single cells or cell clusters will be exerted by laser trapping and sensitively detected by laser interferometry. We furthermore will monitor mechanically triggered transcriptional regulation by detecting mRNA in the nucleus of mouse stem cells differentiating to cardiomyocytes. We will develop fluorescent mRNA sensors that can be imaged in cells, based on near-IR fluorescent single-walled carbon nanotubes. Understanding mechanical cell regulation has far-ranging relevance for fundamental cell biophysics, developmental biology and for human health.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores