Hola,
¿eres nuevo aquí?

Registrate y conecta tu empresa con financiación pública, partners y proyectos.

ForceDelivery

Financiado

Mechanosensitive proteins as a pathway to mechano-targeted drug delivery

Biophysical research over the last two decades has revealed that an impressive number of mechanical signals are key regulators of cell behavior. So far, the focus has been on understanding fundamental mechanosensing and transducti... ver más

31/08/2026

JOHANNES KEPLER UN...

184K€

Presupuesto del proyecto: 184K€

Líder del proyecto

UNIVERSITAT LINZ No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 1 Participantes

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-04-24

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

HORIZON-MSCA-2022-PF-01-01: MSCA Postdoctoral Fellowships 2022

I+D

Cerrada hace 2 años

0% 100%

1 Participantes

JOHANNES KEPLER UNIVERSITAT...

183.60K€ | Lider

Proyectos interesantes

BFU2017-82075-ERC REDES MECANOQUIMICAS EN LA MEMBRANA PLASMATICA 68K€ Cerrado

RTI2018-099718-B-I00 PAPEL DE LOS CANALES MECANO/OSMOSENSIBLES EN LAS FUNCIONES C... 290K€ Cerrado

FJCI-2017-34535 Cell and tissue mecanobiology 50K€ Cerrado

BFU2016-79916-P EL SISTEMA ACOPLADO ENTRE INTEGRINAS Y PROTEINAS ADAPTADORAS... 327K€ Cerrado

BFU2011-23111 ESTUDIO DE LAS VIAS MOLECULARES MECANICAS CELULARES 121K€ Cerrado

BES-2017-080802 EL SISTEMA ACOPLADO ENTRE INTEGRINAS Y PROTEINAS ADAPTADORAS... 93K€ Cerrado

Últimas noticias

25-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 52 concesiones

25-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 1 concesiones

25-11-2024: FUNDACION-EOI En las últimas 48 horas el Organismo FUNDACION EOI ha otorgado 6 concesiones

Duración del proyecto: 40 meses Fecha Inicio: 2023-04-24
Fecha Fin: 2026-08-31

Líder del proyecto

UNIVERSITAT LINZ

TRL 4-5

Presupuesto del proyecto 184K€

Descripción del proyecto Biophysical research over the last two decades has revealed that an impressive number of mechanical signals are key regulators of cell behavior. So far, the focus has been on understanding fundamental mechanosensing and transduction mechanisms in health and disease. As increasing numbers of molecular players and signalling pathways are identified, the time has come to utilize this knowledge for diagnosing and treating diseases where mechanical processes play a role. In this proposal, I aim to target integrins to deliver reporter molecules and drugs to cells with a distinct mechanical phenotype. Integrins are transmembrane receptors through which cells can sense, transmit and discriminate biomechanical forces. During cell adhesion and migration, integrins engage with specific ligands in the extracellular matrix and undergo integrin recycling through continuous endo- and exocytosis. This known endocytic pathway, integrin clustering during adhesion and overexpression in disease states has made integrins a prime target for drug delivery. However, the chemical and physical factors governing integrin-mediated uptake of drugs and their intracellular fate are unknown. I propose to utilize molecular force sensor (MFS) technology to deconvolute the key factors in integrin-mediated drug delivery. Using rational protein design, a series of coiled coil MFSs with distinct chemical (charge and hydrophobicity) and physical (mechanical and thermal stability) properties will be produced. The molecular constructs will be appended with the integrin-targeting RGD motif, a fluorescent protein to investigate the intracellular fate and an actin-binding protein as a model drug that may potentially interfere with the cytoskeleton architecture. This MFS-based drug delivery system will enlighten the pivotal factors of integrin-mediated delivery, provide a diagnostic assay for discriminating cells based on their mechanical phenotype and open up the road towards mechano-targeted drug delivery.

Conecta tu I+D

Entra hoy

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores