Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

MECHANICUS

Financiado

Cerrado

The mechanics of nuclear division and positioning

During mitosis the genetic material of the mother cell is separated and distributed between two daughter cells. Responsible for this coordinated segregation is an assembly of polymers, molecular motors and adapter proteins– the mi... ver más

31/12/2017

FUNDACAO CALOUSTE...

100K€

Presupuesto del proyecto: 100K€

Líder del proyecto

FUNDACAO CALOUSTE GULBENKIAN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2017-12-31 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

FUNDACAO CALOUSTE GULBENKIAN

0.00€ | Lider

Proyectos interesantes

AsterFields

Applied Physics

Medical Technol...

289K€ Cerrado

ASTER

Applied Physics

Medical Technol...

196K€ Cerrado

PGC2018-094090-B-I00

Medical Technol...

Applied Physics

106K€ Cerrado

PLUSTIPS

Applied Physics

Biotechnology

159K€ Cerrado

FJC2020-046386-I

Applied Physics

Medical Technol...

Cerrado

LIVING_FLUCTUATIONS

Applied Physics

Medical Technol...

1M€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Líder del proyecto

FUNDACAO CALOUSTE GULBENKIAN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 100K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto During mitosis the genetic material of the mother cell is separated and distributed between two daughter cells. Responsible for this coordinated segregation is an assembly of polymers, molecular motors and adapter proteins– the mitotic spindle. This super-molecular machine moves the chromosome halves in opposite directions over impressive cellular scales (tens of µm) within a relatively short time (minutes). The regulatory biochemical pathways responsible for timing and error-control of mitosis have been extensively studied and the key factors have been identified. The major mechanical determinants are thought to be a combination of polymerization dynamics and molecular motor activity but what remains elusive is how such individual processes lead to directed movement in a large cytoskeletal assembly, and how active force generation is balanced to prevent structural collapse. Understanding the mechanical properties responsible for pulling chromosomes is at the heart of spindle function, which is critical to the life cycle of a cell. This knowledge is pivotal in developing biomedical applications. Here, I propose to investigate the mechanical basis leading to directed movement of chromosomes during segregation and how mechanical load is distributed in the spindle throughout mitosis. I plan to unravel the molecular nature of force leading to nuclear migration following segregation, an essential process in large egg cells. The experimental foundation for my studies is a recently developed cell-free assay using the genetically tractable Drosophila, providing complete accessibility to every mitotic event with time-lapse imaging and mechanical manipulation. This project lies at the interdisciplinary interface between mechanical engineering, microscopy, biochemistry and fly genetics. The basic concepts for the planned experiments are speckle microscopy, spatial constraining, mechanical relaxation and compression in combination with genetic and pharmaceutical perturbation.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores