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In vitro reconstitution of the S. pombe interphase microtubule cytoskeleton

The research proposed here intends to explore processes governed by microtubule (MT) plus end accumulating proteins (+TIPs) and interdependencies between these proteins for their localisation. The well defined but relatively simpl... ver más

30/04/2010

EMBL

159K€

Presupuesto del proyecto: 159K€

Líder del proyecto

EUROPEAN MOLECULAR BIOLOGY LABORATORY No se ha especificado una descripción o un objeto social para esta compañía.

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2010-04-30 No tenemos la información de la convocatoria

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EMBL

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Líder del proyecto

EUROPEAN MOLECULAR BIOLOGY LABORATORY No se ha especificado una descripción o un objeto social para esta compañía.

Presupuesto del proyecto 159K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The research proposed here intends to explore processes governed by microtubule (MT) plus end accumulating proteins (+TIPs) and interdependencies between these proteins for their localisation. The well defined but relatively simple interphase MT cytoskeleton of Schitzosaccharomyces pombe (S. pombe) has proven to be an excellent model for MT plus end studies. In interphase, MTs are involved in defining sites of polarised growth as well as nuclear positioning by generating pushing forces against the cell cortex. The mechanochemical principles governing this process as well as the likely interplay between +TIPs are as yet incompletely understood. This proposal focuses on elucidating the interdependencies between the various evolutionary conserved +TIPs using (purified proteins of) S. pombe in both in vivo and in vitro experiments. Initial experiments will determine the function of the recently characterised class of length-dependent MT-depolymerases (kinesin-8s) in MT plus end behaviour in S. pombe. Combined with already characterised +TIPs such as Mal3, Tip1, and Tea2, a complete set of proteins, governing all observed MT dynamic behaviours seen in vivo, may now be available. These will be used in an attempt to recreate the first fully functional MT plus end in vitro. Expanding on a novel microscopy set-up created by the Surrey laboratory (EMBL, Heidelberg, Germany, unpublished) we hope to determine the interplay between +TIPs for MT plus end localisation. In addition, we want to investigate the individual as well as the combined influence of these +TIPs on MT dynamic behaviour in vitro. Skills acquired during this research at the interphase of cell biology and biophysics using both in vitro and in vivo techniques will be highly advantageous in obtaining an independent position after the fellowship in these developing fields of biological research.

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