Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

ICSIS

Financiado

Cerrado

The interaction and clearance of senescent vascular cells by the innate immune s...

The interaction and clearance of senescent vascular cells by the innate immune system Cell senescence plays a paradoxical but important role in physiology; it protects organisms against cancer but also contributes to age-related loss of tissue function. Senescent cells accumulate during ageing, particularly at site... ver más

31/05/2017

ASTON U

183K€

Presupuesto del proyecto: 183K€

Líder del proyecto

ASTON UNIVERSITY No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2017-05-31

MSCA-IF-2014-EF: Marie Skłodowska-Curie Individual F...

I+D

Cerrada hace 10 años

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

ASTON U

183.45K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

RTI2018-095818-B-I00 SENESCENCIA CELULAR COMO ESTRATEGIA TERAPEUTICA 182K€ Cerrado

RTI2018-098520-B-I00 SENESCENCIA Y PLASTICIDAD CELULAR EN FISIOLOGIA Y ENFERMEDAD 145K€ Cerrado

PGC2018-102049-B-I00 MECANICA DE LA ARQUITECTURA DE CROMATINA EN EL ENVEJECIMIENT... Cerrado

SENESCENCE CLEARANCE Mechanisms of immune surveillance of senescent cells 100K€ Cerrado

SAF2016-81897-REDT SENESCENCIA CELULAR: DE MECANISMOS A TERAPIAS. 20K€ Cerrado

STEM-AGING Tissue regeneration and aging the decisive quiescent stem c... 2M€ Cerrado

Duración del proyecto: 25 meses Fecha Inicio: 2015-04-17
Fecha Fin: 2017-05-31

Líder del proyecto

ASTON UNIVERSITY No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 183K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Cell senescence plays a paradoxical but important role in physiology; it protects organisms against cancer but also contributes to age-related loss of tissue function. Senescent cells accumulate during ageing, particularly at sites of age-related pathologies such as vascular tissue, contributing to fibrotic cardiovascular disease , . Therefore, the aim of this research is to understand why senescent cells accumulate later in life for the purpose of identifying potential therapeutic strategies for eliminating senescent cells. This project, founded in an emerging field of ageing research, will determine the interaction and clearance of senescent cells by ageing innate immune cells. Using in vitro, ex vivo and in vivo approaches the fellow will delineate the mechanisms of interaction between senescent vascular cells and the innate immune system and how they are impacted by age. This will significantly advance knowledge and lead to novel molecular targets to explore for eliminating age-associated vascular senescent cells. Since the field of cellular senescence is predominantly centred within molecular cell biology and cancer, this coordinated cross-disciplinary and cross-sectorial approach will provide novel insight into vascular senescence. Through an ambitious research training programme, the fellow will develop scientific, complementary and transferable skills in metabolism, innate immunity and vascular function in age-related disease from Aston, UK with intersectorial training to develop small molecule drugs from Redoxis SB, SWE; evaluate drug efficacy in models of ageing (Erasmus, NL); in the context of clinical cardiology (Aston/City Hospital, UK). It will deepen collaborations for partners, provide new techniques to the hosts and enhance the skills of exceptionally talented research fellow, with over ten years’ experience in the field of cellular senescence, forward as a research leader with experience of working effectively across sectors.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores