Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

OviChip

Financiado

The biofabrication of a 3D in vitro human oviduct model to study infertility and...

The biofabrication of a 3D in vitro human oviduct model to study infertility and factors affecting embryo development Despite being viewed as a simple transport conduit, the oviduct can determine a successful pregnancy and has a life-long impact on our health and wellbeing. Also called the fallopian tube, our understanding of tubal function remai... ver más

31/12/2027

UNIVERSITEIT MAAST...

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

UNIVERSITEIT MAASTRICHT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-11-08

ERC-2021-STG: ERC STARTING GRANTS Scope:Objectives

I+D

Cerrada hace 3 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UNIVERSITEIT MAASTRICHT

2.32M€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

AGL2012-40180-C03-01 DESCRIPCION DE NUEVAS RUTAS FISIOLOGICAS QUE CONTRIBUYEN AL... 216K€ Cerrado

PDC2022-133587-I00 SELECCION DE OOCITOS PARA LA FERTILIZACION IN VITRO: PREDICC... 138K€ Cerrado

PID2020-114109GB-I00 SPERM-EGG RECOGNITION ENTAILS NEW INSIGHT IN DEVELOPING ASSI... 171K€ Cerrado

SAF2017-87526-R BUSQUEDA DE BIOMARCADORES Y DESAROLLO DE UN TEST MOLECULAR D... 228K€ Cerrado

PID2019-111376RA-I00 SELECCION DE EMBRIONES PARA FECUNDACION IN VITRO: PREDICCION... 133K€ Cerrado

Duración del proyecto: 61 meses Fecha Inicio: 2022-11-08
Fecha Fin: 2027-12-31

Líder del proyecto

UNIVERSITEIT MAASTRICHT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto Despite being viewed as a simple transport conduit, the oviduct can determine a successful pregnancy and has a life-long impact on our health and wellbeing. Also called the fallopian tube, our understanding of tubal function remains limited, owing to the ethical limitations of human studies and the poor translations of animal studies to people. The objective of the OviChip project is to create the first full-scale 3D in vitro model of the oviduct that can address our knowledge gap. The oviduct selects healthy sperm and hosts the first embryonic cell divisions, setting the stage for fetal development and health in our adult life. Epigenetic factors can trigger genetic defects in these first moments that lead to unsuccessful pregnancies or ailments such as Alzheimer’s, Diabetes, and schizophrenia. When oviduct function is compromised, such as through a Chlamydia Trachomatis infection, infertility can arise. A common recourse for prospective parents is in vitro fertilization (IVF). However, IVF success rates have plateaued at 30% for the past decade and concerns have emerged about the epigenetic impact IVF has on a child’s health. Therefore, to improve embryo viability and IVF outcomes or to avoid IVF by addressing tubal pathologies, our knowledge gap about oviduct function must be addressed. The OviChip project will develop biofabrication technologies to create a 3D model that respects the structural and biological elements of the oviduct from a meso to micron scale. The anticipated outcomes include: 1) the validation of new biofabrication approaches; 2) a better understanding of Chlamydia-associated tubal pathologies; 3) insight into the oviduct microenvironment with respect to sperm selection and epigenetic factors affecting embryogenesis. The OviChip will strive for unprecedented biomimicry and functional readout, setting new standards for tissue engineering. Most importantly, this will provide a unique avenue to fundamental answers that impact patients.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores