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SARM

Financiado

Cerrado

Endometrial and embryonic genomics searching for biomarkers in assisted reprodu...

Endometrial and embryonic genomics searching for biomarkers in assisted reproduction short title Search for Assisted Reproduction Markers Infertility is a serious medical concern preventing the parenthood in 10% of couples. Infertility treatment using assisted reproduction techniques (ART) is popular in Europe with up to 5% of children born thanks to medical help. D... ver más

31/12/2016

CELVIA CC AS

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

CELVIA CC AS No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 5 Participantes

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2016-12-31 No tenemos la información de la convocatoria

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

5 Participantes

CELVIA CC AS

0.00€ | Lider

KU Leuven

N.D. | Participante

IGENOMIX

N.D. | Participante

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Líder del proyecto

CELVIA CC AS No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 3M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Infertility is a serious medical concern preventing the parenthood in 10% of couples. Infertility treatment using assisted reproduction techniques (ART) is popular in Europe with up to 5% of children born thanks to medical help. Despite many technological improvements the overall pregnancy rate after infertility treatment using the most commonly practiced in vitro fertilization (IVF) remains only 30% per single cycle. The specific features of human reproduction include the high prevalence of diverse chromosomal pathologies in oocytes and early embryos, and significant dysregulation in gene expression in embryo and endometrial tissue, both being the risk factors for implantation failure and decreased pregnancy rate after IVF. Hence, the intrinsic motivation for the current SARM project stems from the perceived need to contribute to future IVF improvements and benefit from the recent breakthroughs in technological innovations. Our primary research objective is to unravel the molecular nature of human preimplantation embryo development and endometrial maturation. This ambitious goal will be achieved by exploiting highly sophisticated single-cell genomics tools, such as fine-resolution mapping of DNA copy-number changes by using SNP-arrays and sequencing platforms, and characterizing single-cell transcriptional landscape by RNA-sequencing. These studies are likely to propose novel embryonal and endometrial biomarkers useful for selecting the most competent embryos for transfer or identifying the causes of female infertility of endometrial origin. The SARM consortium consists of 2 industrial (IVIOMICS, Paterna/Spain and Competence Centre on Reproductive Medicine, Tartu/Estonia) and 3 academic (Karolinska Institute, Stockholm/Sweden; Katholieke Universiteit Leuven, Belgium and University of Tartu/Estonia) partners, forming a strong, stimulating and coherent research environment ensuring the pooling of complementary scientific skills in reproductive genetics and medicine.

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