Study of the role of apolipoprotein E apoE a key component of the lipid and l...
Study of the role of apolipoprotein E apoE a key component of the lipid and lipoprotein transport system in the development of obesity related osteoarthritis
Osteoarthritis (OA) is the most common disease of the joints. However, the molecular mechanisms that are involved in its pathogenesis are still unclear. One of the major causes of OA is obesity. The past few years a lot of studies...
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Información proyecto APOEOSTEOARTHRITIS
Líder del proyecto
PANEPISTIMIO PATRON
No se ha especificado una descripción o un objeto social para esta compañía.
TRL
4-5
Presupuesto del proyecto
100K€
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
Osteoarthritis (OA) is the most common disease of the joints. However, the molecular mechanisms that are involved in its pathogenesis are still unclear. One of the major causes of OA is obesity. The past few years a lot of studies have focused on the functional link between adipose tissue and cartilage in the development of OA. It has been recently shown that apolipoprotein E (apoE) over-expression promotes diet-induced obesity in mice. In addition, in vitro studies have demonstrated that apoE gene deficiency enhances the reduction of bone in mice fed high-fat diet, while lack of ApoE leads to increased bone formation in mice fed chaw diet. Triggered by these findings, in the present proposal the applicant will use in vivo, biochemical and molecular methodologies in order to investigate the role of ApoE in the pathobiology of obesity-induced OA in mice and explore its implication in the development and progression of OA in humans.