Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

HSP70-TAU NMR

Financiado

Cerrado

Structural analysis of the conformational transitions of the K18 fragment of hum...

Structural analysis of the conformational transitions of the K18 fragment of human tau driven by Hsp70 action The proteins Tau and α-synuclein are causative agents of several neurodegenerative diseases including Alzheimer’s and Parkinson’s disease. In physiological conditions these neurotoxic proteins adopt a disordered conformation but u... ver más

30/04/2016

BUNDESMINISTERIUM...

169K€

Presupuesto del proyecto: 169K€

Líder del proyecto

BUNDESMINISTERIUM FUER GESUNDHEIT No se ha especificado una descripción o un objeto social para esta compañía.

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2016-04-30 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

BUNDESMINISTERIUM FUER GESUN...

0.00€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

HSP70ASYN Structural studies of the interaction between Hsp70 and alph... 210K€ Cerrado

DETECTAMYLOID Detection of membrane interacting cytotoxic amyloid intermed... 162K€ Cerrado

PID2019-109276RA-I00 BASES ESTRUCTURALES DE LA TOXICIDAD DE ENSAMBLADOS TEMPRANOS... 157K€ Cerrado

cofacTau Cofactors at the core of tau prion behaviour 1M€ Cerrado

LipiSyn Study of membrane lipid composition and alpha-synuclein spre... 196K€ Cerrado

BFU2016-75983-P DESAGREGASAS HUMANAS COMO UNA HERRAMIENTA TERAPEUTICA EN NEU... 151K€ Cerrado

Líder del proyecto

BUNDESMINISTERIUM FUER GESUNDHEIT No se ha especificado una descripción o un objeto social para esta compañía.

Presupuesto del proyecto 169K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The proteins Tau and α-synuclein are causative agents of several neurodegenerative diseases including Alzheimer’s and Parkinson’s disease. In physiological conditions these neurotoxic proteins adopt a disordered conformation but undergo conformational transitions leading to their aggregation and amyloid fibril formation under neuronal stress. ATP-driven molecular chaperones of the heat-shock protein (Hsp) family have been postulated to play a critical role in inhibiting the gain-of-toxic function of these proteins. However, little is known about the binding and activation mechanism of neurotoxic proteins, and of disordered proteins in general, induced by Hsps. Given the dynamic and unstable nature of these interactions and activation cycles, NMR spectroscopy is ideally suited to obtain insight into the nature of these interactions. In the attached application I propose to obtain - by means of novel artful NMR experimental designs, complemented with extensive biochemical and biophysical characterization - a detailed model of the aggregation-prone fragment of Tau bound to the two different allosteric conformations of Hsp70. This will for the first time shed light onto the still unsolved conformational changes in a client protein motivated by the chaperone mode of action. Moreover, I will study several disease-related Tau mutants, the role of cochaperones in this cycle, as well as the effect of inhibitors to better understand the mechanism of Hsp-substrate interaction. In addition, the detailed structural information that will be obtained in this project will provide the basis to chemically optimize available inhibitors and test their cellular effect in the last phase of the project. The opportunity to carry out this ambitious project represents a significant step forward for my future independent career, being deeply involved in state-of-the-art methodological and biological tutoring in a scientific environment that is tightly connected to the industry sector.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores