Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

3D-REG

Financiado

Shedding light on three-dimensional gene regulation

The orchestration of precise gene expression patterns during differentiation and development is dependent on the cis-regulatory elements of the genome, which interact and communicate in three-dimensional (3D) chromatin structures.... ver más

31/12/2028

MPG

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

MAXPLANCKGESELLSCHAFT ZUR FORDERUNG DER WISSE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-10-16

ERC-2023-STG: ERC STARTING GRANTS Scope:Objectives

I+D

Cerrada hace 2 años

0% 100% 100%

1 Participantes

MPG

1.50M€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

BFU2013-42709-P DINAMICA DE LA ORGANIZACION NUCLEAR DURANTE EL DESARROLLO AN... 254K€ Cerrado

Totipotency Transcriptional and Epigenetic Regulation of Totipotency in... 3M€ Cerrado

BioMeTRe Biophysical mechanisms of long range transcriptional regulat... 2M€ Cerrado

BFU2016-79699-P CONTROL TRANSCRIPCIONAL A LARGAS DISTANCIAS POR ENHANCERS: L... 139K€ Cerrado

XPRESS Exploring mechanisms of gene repression and escape during X... 2M€ Cerrado

TE-Time Dissecting host-transposon interactions during germline deve... 196K€ Cerrado

Duración del proyecto: 62 meses Fecha Inicio: 2023-10-16
Fecha Fin: 2028-12-31

Líder del proyecto

MAXPLANCKGESELLSCHAFT ZUR FORDERUNG DER WISSE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto The orchestration of precise gene expression patterns during differentiation and development is dependent on the cis-regulatory elements of the genome, which interact and communicate in three-dimensional (3D) chromatin structures. It is not well understood how these interactions are formed and influence gene expression. Our ability to identify the molecular mechanisms involved is hampered by a lack of tools that provide control over the function of regulatory proteins with high temporal precision and that measure 3D chromatin interactions at high resolution. In this project, we will overcome these hurdles by utilizing an ultra-fast optogenetic system that allows for efficient and reversible nuclear depletion of mammalian proteins upon blue light exposure. We will combine this approach with a range of high-resolution genomic tools to investigate the context-specific functions of transcription factors, co-activators, and architectural proteins throughout erythroid differentiation. Importantly, our set-up does not only allow for characterisation of acute protein depletion, but also enables us to map the molecular events triggered by restoration of regulatory proteins to the nucleus. This unique approach will therefore provide detailed insight into their molecular functions. Moreover, to get a more complete overview of the proteins involved in gene activation, we will implement a locus-specific proteomics approach that enables unbiased identification of the proteome of regulatory regions. This innovative integrated research program has strong potential to transform our understanding of the molecular mechanisms that shape the genome and drive gene activation during cellular differentiation. Furthermore, it will lead to the development of cutting-edge tools to analyse gene regulation in its 3D context at high temporal and spatial resolution.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores